Program - Society of Toxicology

44 th Annual Meeting
and ToxExpo
Program Description
#217 INDUCTION OF INFLAMMATORY MEDIATORS
AND ANTIOXIDANTS FOLLOWING EXPOSURE
OF MACROPHAGES TO PARAQUAT. R.
Mukhopadhyay 1 , J. P. Gray 1 , D. E. Heck 2 , A. T. Black 1 ,
V. M. Mishin 2 , M. Thiruchelvam 1 , D. A. Cory-Slechta 1
and J. D. Laskin 1 . 1 Environmental and Occupational
Medicine, UMDNJ-Robert W Johnson Med. School,
Piscataway, NJ and 2 Pharmacology and Toxicology,
Rutgers University, Piscataway, NJ.
#218 ASCORBATE INHIBITS UROPORPHYRIA IN
ASCORBATE-REQUIRING MICE. P. R. Sinclair 1,2 ,
N. Gorman 1,2 , H. W. Trask 1,2 , A. Zaharia 1,2 and J. F.
Sinclair 1,2 . 1 Research, VA Med. Ctr, White River
Junction, VT and 2 Biochem/Pharmacol-Toxicol,
Dartmouth Med. School, Hanover, NH.
#219 DETERMINATION OF PARAMETERS
INDICATIVE FOR OXIDATIVE STRESS IN
CARBON TETRACHLORIDE TREATED RATS. P.
Sagelsdorff 1 and Y. Balduchelly 2 . 1 Mechanistic
Toxicology, RCC Ltd., Fuellinsdorf, Switzerland and
2 Chimie, HEVs, Sion, Switzerland. Sponsor: K.
Sachsse.
#220 6-HYDROXYDOPAMINE ACTIVATES THE
ANTIOXIDANT RESPONSE ELEMENT
THROUGH A COMBINATION OF OXIDATIVE,
EXCITOTOXIC, AND STRUCTURAL FACTORS.
R. J. Jakel 1,2,3 , J. T. Kern 3 , D. A. Johnson 3 and J. A.
Johnson 1,3 . 1 Neuroscience Training Program, University
of Wisconsin, Madison, WI, 2 Medical Scientist Training
Program and UW Medical School, University of
Wisconsin, Madison, WI and 3 Pharmaceutical Sciences,
University of Wisconsin, Madison, WI.
#221 ACTIVATION OF TRANSCRIPTION FACTOR
AP-1 IN ANILINE-INDUCED SPELENIC
TOXICITY. S. -. Kannan, J. -. Wang and M. Khan.
Pathology, Univesrity of Texas Medical Branch,
Galveston, TX.
#222 DOWN-REGULATION OF NITRIC OXIDE AND
ANTIOXIDANT SYSTEMS IN ALCOHOL-
INDUCED HYPERTENSION. K. Husain, J. Lalla and
S. Kazim. Pharmacology and Toxicology, Ponce School
of Medicine, Ponce, Puerto Rico.
#223 HO-1 INDUCTION CONTRIBUTES TO PCB-
INDUCED OXIDATIVE STRESS IN
DOPAMINERGIC CELLS. D. W. Lee, R. M. Gelein
and L. A. Opanashuk. Department of Environmental
Medicine, University of Rochester School of Medicine
and Dentistry, Rochester, NY.
#224 REACTIVE OXYGEN/NITROGEN SPECIES IN
ACETAMINOPHEN (APAP) TOXICITY IN
FRESHLY ISOLATED MOUSE HEPATOCYTES.
A. B. Reid and J. A. Hinson. Pharmacology, University
of Arkansas for Medical Sciences, Little Rock, AR.
#225 ACETAMINOPHEN INDUCED HEPATOXICITY
IN A GCLM- NULL MOUSE MODEL. L.
McConnachie 1 , C. Fernandez 1 , I. Mohar 1 , R. Pierce 2
and T. Kavanagh 1 . 1 Department of Environmental and
Occupational Health Sciences, University of
Washington., Seattle, WA and 2 Department of Pathology
and Lab. Medicine, University of Rochester, Rochester,
NY.
#226 INDUCTION OF METALLOTHIONEIN
SYNTHESIS MEDIATED THROUGH OXIDATIVE
STRESS IN MITOCHONDRIA AND ITS
BIOLOGICAL ROLE. M. Sato. Faculty of Pharmacy,
Tokushima Bunri University, Tokushima, Japan.
#227 HEPATOCYTE-SPECIFIC DELETION OF GCLC
RESULTS IN PROGRESSIVE LOSS OF
MITOCHONDRIAL FUNCTION. Y. Chen, D. Shen,
H. G. Shertzer, M. L. Miller, S. N. Schneider, D. W.
Nebert and T. P. Dalton. Environmental Health,
University of Cincinnati Medical Center, Cincinnati,
OH.
#228 A NOVEL HALOENOL LACTONE DERIVATIVE
INDUCES OXIDATIVE STRESS IN HUMAN
TUMOR CELLS THROUGH A GLUTATHIONE S-
TRANSFERASE MEDIATED MECHANISM. W.
Wang and J. Zheng. Pharmaceutical Sciences,
Northeastern University, Boston, MA.
#229 IDENTIFICATION AND CHARACTERIZATION
OF BIOACTIVE COMPOUNDS FROM TOBACCO
AS INHIBITORS OF NEURONAL NITRIC OXIDE
SYNTHASE. P. Venkatakrishnan 1 and T. R. Miller 1 .
1 Graduate Center for Toxicology, University of
Kentucky, Lexington, KY and 2 Graduate Center for
Toxicology, University of Kentucky, Lexington, KY.
Monday Morning, March 7
9:30 AM to 12:30 PM
Exhibit Hall
POSTER SESSION: METHYL IODIDE RISK ASSESSMENT
Chairperson(s): Michael Gargas, Sapphire Group Inc., Dayton, OH and Lisa
Sweeney, The Sapphire Group, Dayton, OH.
Displayed: 9:30 AM–12:30 PM
Attended: 9:30 AM–11:00 AM
#230 DEVELOPMENT AND VALIDATION OF AN
ASSAY FOR IODIDE IN SERUM USING ION
CHROMATOGRAPHY WITH AMPEROMETRIC
DETECTION. E. Kaiser 1 , J. M. Flaherty 1 , M. W.
Himmelstein 2 and J. H. Kinzell 3 . 1 Exygen Research,
Inc., State College, PA, 2 DuPont Haskell Laboratory for
Health and Environmental Sciences, Newark, DE and
3 Arvesta Corporation, San Francisco, CA.
#231 METHYLATION OF HEMOGLOBIN CYSTEINE
AS A BIOMARKER OF EXPOSURE TO
IODOMETHANE. D. L. Nabb 1 , M. W. Himmelstein 1 ,
M. P. Delorme 1 , E. Sloter 3 , M. L. Gargas 2 , J. H.
Kinzell 4 and R. A. Kemper 1 . 1 DuPont Haskell
Laboratory, Newark, DE, 2 The Sapphire Group, Dayton,
OH, 3 WIL Research Laboratories, Ashland, OH and
4 Arvesta Corporation, San Fransisco, CA.
#232 UPTAKE OF METHYL IODIDE IN THE NASAL
CAVITY OF RATS AND RABBITS. K. D. Thrall 1 , A.
D. Woodstock 1 , J. J. Soelberg 1 , J. H. Kinzell 2 and M. L.
Gargas 3 . 1 Battelle, Pacific Northwest Division,
Richland, WA, 2 Arvesta Corp., San Francisco, CA and
3 The Sapphire Group, Inc., Beavercreek, OH.
MONDAY
up-to-date information at www.toxicology.org 65