Program - Society of Toxicology

44 th Annual Meeting
and ToxExpo
Program Description
TUESDAY
1:15 PM–2:45 PM Workshop Session II (break out rooms)
2:45 PM–3:15 PM Paracelsus in Practice (Room 213)
Moderator: David Cragin, Merck and Company,
Inc., Whitehouse Station, NJ.
3:15 PM–3:30 PM Program Conclusion and Evaluation
Kenneth McMartin, LSU Health Science Center,
Shreveport, LA.
3:30 PM–4:30 PM Visit ToxExpo
Tuesday Morning, March 8
8:30 AM to 9:30 AM
Room 223
INFORMATIONAL SESSION: THE ROSETTA RESOLVER®
SYSTEM: AN ENTERPRISE SOLUTION FOR GENE EXPRESSION
ANALYSIS AND PREDICTIVE TOXICOLOGY
The Rosetta Resolver® System, an enterprise gene expression analysis solution,
is a cornerstone in drug discovery for routinely processing and managing data
from thousands of high-density microarrays. This presentation will focus on the
current challenges of toxicogenomics data analysis in drug development, and
how the use of the Resolver system addresses those challenges.
Tuesday Morning, March 8
8:30 AM to 11:30 AM
Room RO2
SYMPOSIUM SESSION: ALTERED IRON HOMEOSTASIS (AIH) AS A
BASIS FOR PULMONARY IMMUNOTOXICOLOGIC EFFECTS OF
PARTICULATE MATTER
Chairperson(s): Mitch Cohen, New York University School of Medicine,
Tuxedo, NY and Andrew Ghio, National Health & Environmental Effect
Research Laboratory, Chapel Hill, NC.
Endorsed by:
Immunotoxicology SS*
Inhalation Specialty Section
Student Advisory Committee
The scientific literature is replete with reports on the pulmonary toxicologic and
immuno-toxicologic effects of particulate matter (PM). Although it has become
increasingly accepted that the composition of PM is a major factor influencing
biological effects, mechanisms to describe how composition might induce
observed toxicities are mostly lacking. The altered iron homeostasis (AIH)
theory postulates that specific components in PM induce alterations in the levels
of free catalytically-active iron within the lungs as well as in iron availability to
both lung epithelial and immune cells. These changes, in turn, impact upon local
responses to infectious agents and allergens, as well as upon the release of cell
products that might contribute to cardiopulmonary changes. The AIH theory not
only provides a basis to explain how select PM constituents might induce these
effects, but also how day-to-day or regional differences in the amounts of these
components (relative to that of iron) may underlie the variability in reported
health effects induced with equivalent doses of differing PM samples. Following
introductory talks about the role of iron homeostasis in maintenance of immune
cell functions and how components of PM may be selectively mobilized, this
symposium will highlight specifically how AIH could be the basis for the
observed alterations in allergic, immunologic, and cardiopulmonary responses
after host exposures to PM.
#636 8:30 ALTERED IRON HOMEOSTASIS (AIH) AS A
BASIS FOR PULMONARY
IMMUNOTOXICOLOGIC EFFECTS OF
PARTICULATE MATTER. M. Cohen. Environmental
Medicine, New York University, Tuxedo, NY.
#637 8:35 THE ROLE OF IRON (FE) HOMEOSTASIS IN
IMMUNE CELL FUNCTIONALITY. C. L. Bowlus.
Department of Internal Medicine, University of
California Davis Medical Center, Sacramento, CA.
Sponsor: M. Cohen.
#638 9:10 MOBILIZATION OF METALS FROM
PARTICLES: IMMUNOTOXICOLOGIC
IMPLICATIONS. A. E. Aust. Department of
Chemistry and Biochemistry, Utah State University,
Logan, UT.
#639 9:45 METALS, PARTICLES AND IMPACT UPON
PULMONARY ALLERGIC RESPONSES. M.
Gilmour. National Health and Environmental Effects
Research Laboratory, U.S. EPA, Research Triangle
Park, Durham, NC.
#640 10:20 EFFECTS OF PARTICLES ON FE TRANSPORT
AND THE IMMUNOTOXICOLOGIC
OUTCOMES. A. J. Ghio. National Health and
Environmental Effects Research Laboratory, U.S. EPA,
Research Triangle Park, NC.
#641 10:55 DO ALTERED FE STATUS-INDUCED EFFECTS
ON TRANSCRIPTION FACTORS HAVE A ROLE
IN PM-INDUCED
PULMONARY/CARDIOVASCULAR DISEASES?
K. Salnikow. Laboratory of Comparative
Carcinogenesis, National Cancer Institute, Frederick,
MD.
Tuesday Morning, March 8
8:30 AM to 11:30 AM
Room 208
SYMPOSIUM SESSION: BEYOND LIVER TOXICOGENOMICS:
GENE EXPRESSION BASED BIOMARKERS IN NON-HEPATIC
TISSUES
Chairperson(s): Kyle Kolaja, Iconix, Mountain View, CA and David J. Dix,
National Health & Environmental Effects Research Laboratory, Research
Triangle Park, NC.
Endorsed by:
Carcinogenesis SS
Toxicologic and Exploratory Pathology SS
Toxicogenomics, the genome scale analysis of chemically induced changes in
complex populations of mRNA to understand toxicity, has already dramatically
impacted predictive and mechanistic toxicology. Gene expression based
biomarkers can provide a precise and rapid assessment of toxicity or exposure,
but most toxicogenomics efforts to date have been conducted in liver due to toxicological
interest, technical ease of data creation, relative homogeneity of tissue
sample, and historical inertia. Recently analysis of gene expression data in nonhepatic
organs and tissues has started to gain momentum, and this session will
include presentations of significant and promising examples ranging from toxicogenomic
analyses of vascular, cardiac, kidney, neural and reproductive tissues
treated with various drugs, chemicals, and toxicants. From these burgeoning
studies, researchers are identifying biomarkers predictive of toxicity and indicative
of various mechanisms and pharmacology in non-hepatic tissues.
#642 8:30 BEYOND LIVER TOXICOGENOMICS: GENE
EXPRESSION BASED BIOMARKERS IN NON-
HEPATIC TISSUES. K. L. Kolaja. Toxicology, Iconix
Pharmaceuticals, Mountain View, CA.
98
SOT’s 44 th Annual Meeting