Program - Society of Toxicology

44 th Annual Meeting
and ToxExpo
Program Description
#709 INTERINDIVIDUAL VARIATION OF
EXPRESSION LEVEL OF CYP3A4 AND ITS
RELATED PHARMACOGENETIC GENES IN
JAPANESE LIVER TISSUE. A. Miyajima-Tabata 1 , S.
Ozawa 1 , J. He 1 , H. Tanaka 2 , K. Nakai 2 , M. Sunouchi 1 ,
Y. Kamikawa 3 , K. Kubota 4 , H. Ogata 2 and Y. Ohno 1 .
1 Division of Pharmacology, National Institute of Health
Sciences, Setagaya, Tokyo, Japan, 2 Department of
Biopharmaceutics, Meiji Pharmaceutical University,
Kiyose, Tokyo, Japan, 3 Department of Pharmacology,
Dokkyo University School of Medicine, Mibu, Tochigi,
Japan and 4 Second Department of Surgery, Dokkyo
University School of Medicine, Mibu, Tochigi, Japan.
Sponsor: M. Ema.
#710 USE OF NOVEL MULTIPLEXED QPCR ASSAYS
TO ACCURATELY QUANTIFY HUMAN
CYTOCHROME P450 EXPRESSION. R. D.
Larsen 1 , C. Chang 1 , M. Tan 1 , C. Patten 2 and S. Parikh 2 .
1 2 BD Biosciences Clontech, Palo Alto, CA and BD
Biosciences Discovery Labware, Billerica, MA.
Sponsor: D. Stresser.
#711 USING P450-GLO LUMINESCENT ASSAYS TO
SCREEN FOR XENOBIOTIC EFFECTS ON
CYTOCHROMES P450. J. Cali 1 , D. Liu 1 , R. Bulliet 1
and D. Ma 1 . 1 Promega Corp, Madison, WI and 2 R&D,
Promega Biosciences, Sac Louis Obispo, CA.
#712 DIOXIN AND DIET EFFECTS ON GROWTH AND
P450 INDUCTION. M. La Merrill 1 and D. W.
Threadgill 2,1 . 1 Curriculum in Toxicology, UNC-CH,
Chapel Hill, NC and 2 Genetics, UNC-CH, Chapel Hill,
NC.
#713 DIOXIN INDUCTION OF CYP1A1 EXPRESSION
IS SUPPRESSED IN HEPATITIS C VIRUS
REPLICATING CELLS. G. R. Anderson, A. Hasan, I.
Qadri and L. C. Quattrochi. Medicine, University of
Colorado Health Sciences Ctr, Denver, CO.
#714 DIFFERENTIAL REGULATION OF LIVER
MITOCHONDRIAL CYTOCHROME P4501A1
(P450MT2) BY 3-METHYLCHOLANTHRENE IN
MICE DEFICIENT IN THE CYTOCHROME
P4501A2 GENE. B. Moorthy, S. Kondraganti and W.
Jiang. Pediatrics, Baylor College of Medicine, Houston,
TX.
#715 ENDOGENOUS SUBSTRATES OF CYP1B1
WHICH MAY BE ENDOGENOUS LIGANDS OF
THE ARYL HYDROCARBON RECEPTOR. B.
Stapleton 1 , A. Annalora 1 , C. Chiaro 5 , M. Doshi 3 , A.
Bailey 1 , J. Omdahl 2 , B. Bejjani 4 , D. Edward 3 , G.
Perdew 5 and C. Marcus 1 . 1 Toxicology, University New
Mexico, Albuquerque, NM, 2 Biochemistry, University
New Mexico, Albuquerque, NM, 3 Opthalmology &
Visual Sciences., University IL, Chicago, IL, 4 Genetics
& Pediatrics, WA. St. University, Spokane, WA and
5 Cell & Molecular Biology, Penn. St. University,
University Park, PA.
#716 THE RESPONSE OF THE RAT HEPATIC P450
SYSTEM TO FIVE ARCHETYPAL HUMAN
MICROSOMAL ENZYME INHIBITORS. S. J.
Schomaker, S. E. Boldt and D. E. Amacher. Safety
Sciences Groton, Pfizer Inc., Groton, CT.
#717 EFFECTS OF DIESEL EXHAUST PARTICLES ON
CYTOCHROME P450 ACTIVITIES IN PRIMARY
CULTURES OF ADULT RAT HEPATOCYTES: A
USEFUL INDICATOR FOR THE STUDY OF
HEALTH RISK. T. Jeon 1 , S. Hyun 1 , S. Lee 1 , C. Jin 1 ,
D. Lee 1 , G. Kim 1 , I. Jun 1 , K. Chung 2 , C. Moon 3 and T.
Jeong 1 . 1 College of Pharmacy, Yeungnam University,
Kyungsan, South Korea, 2 College of Pharmacy,
Sungkyunkwan University, Suwon, South Korea and
3 College of Pharmacy, Seoul National University, Seoul,
South Korea.
#718 IN VITRO EVALUATION OF HISTAMINE AND
ITS MAJOR METABOLITES AS INHIBITORS OR
INDUCERS OF CYTOCHOME P450
EXPRESSION IN HUMAN LIVER. S. A. Tonetta 1 , F.
Nodikum-Moffor 2 , B. L. Paris 2 and B. M. Richard 1 .
1 Nonclinical, Maxim Pharmaceuticals, San Diego, CA
and 2 Metabolism, Xenotech LLC, Lenexa, KS.
#719 COMPARATIVE STUDIES OF CYTOCHROME
P4503A4 INDUCTION RESPONSE IN PRIMARY
CULTURES OF CRYOPRESERVED AND FRESH
HUMAN HEPATOCYTES. J. Johnson 1 , C. M.
Chandler 1 , S. Kim 2 , L. Tarabelsi 1 , D. M. Stresser 1 , M.
Sinz 2 and J. G. Zhang 1 . 1 BD Discovery Labware,
woburn, MA and 2 Bristol Myers Squibb Co.,
Wallingford, CT.
#720 REGULATIONS OF HUMAN CYP3A4
PROXIMAL AND XREM PROMOTER
ACTIVITIES IN HEPA I AND HEPG2 CELLS. Y. Y.
Sheen, K. N. Min, J. Y. An, K. E. Joung, Y. W. Kim and
D. Kim. Pharmacy, Ewha Womans University, Seoul,
seoul, South Korea. Sponsor: J. Chung.
#721 ROLE OF NF-κB IN REGULATION OF PXR
TRANSCRIPTIONAL ACTIVITY: A
MECHANISM FOR THE SUPPRESSION OF
CYTOCHROME P450 3A4 BY INFLAMMATORY
AGENTS. X. Gu 1 , T. Sheng 2 , S. Ke 1 , P. E. Thomas 3 ,
M. A. Gallo 3 , W. Xie 4 and Y. Tian 1 . 1 Interdisciplinary
Faculty of Toxicology, College Station, TX, 2 The
University of Texas Medical Branch, Galveston, TX,
3 EOHSI, Rutgers University, Piscataway, NJ and
4 University of Pittsburgh, Pittsburgh, PA.
#722 DOWN-REGULATION OF HEPATIC
CYTOCHROME P450S IN ENDOTOXEMIC
MICE IS INDEPENDENT OF PEROXISOME
PROLIFERATOR ACTIVATED RECEPTOR
ALPHA (PPARα). T. Richardson and E. T. Morgan.
Pharmacology, Emory University, Atlanta, GA.
#723 GENERATION AND CHARACTERIZATION OF A
TRANSGENIC MOUSE MODEL WITH HEPATIC
EXPRESSION OF HUMAN CYP2A6. J. Gu, Q.
Zhang, T. Su, H. Cui, X. Zhuo, P. J. Swiatek, L. Zhang,
W. Yang and X. Ding. Wadsworth Center, Albany, NY.
TUESDAY
up-to-date information at www.toxicology.org 105