Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description MONDAY #143 ALTERED PROTEIN EXPRESSION FOLLOWING IN UTERO EXPOSURE TO ARSENIC. C. Lantz, J. S. Petrick and A. M. Hays. Cell Biology and Anatomy, University of Arizona, Tucson, AZ. #144 ABERRANT GENE EXPRESSION IN THE NEONATAL MOUSE LUNG FOLLOWING IN UTERO EXPOSURE TO INORGANIC ARSENIC. J. Shen 1 , Y. Xie 1 , J. Liu 1 , B. Diwan 2 and M. Waalkes 1 . 1 Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, NC and 2 BRP, SAIC- Frederick, NCI at Frederick, Frederick, MD. #145 ARSENIC INDUCES CHROMOSOMAL AND CENTROMERIC ABNORMALITIES, IN HUMAN LUNG CELLS. J. P. Lynch 1,2 , S. S. Wise 1,2 and J. P. Wise 1,2 . 1 Wise Laboratory of Environmental and Genetic Toxicology, University of Southern Maine, Portland, ME and 2 Maine Center for Toxicology and Environmental Health, University of Southern Maine, Portland, ME. #146 CHARACTERIZATION OF HUMAN BLADDER UROTHELIAL CELLS MALIGNANTLY TRANSFORMED BY ARSENITE. K. E. Billings 1 , T. G. Bredfeldt 1 , X. H. Zheng 1 , M. J. Kopplin 1 , G. S. Watts 2 , D. A. Sens 4 , E. A. Mash 3 and A. J. Gandolfi 1 . 1 Depts of Pharmacology and Toxicology, University of AZ, Tucson, AZ, 2 AZ Cancer Center, University of AZ, Tucson, AZ, 3 Department of Chemistry, University of AZ, Tucson, AZ and 4 Depts of Pathology and Surgery, School of Medicine and Health Sciences, University of ND, Grand Forks, ND. #147 ARSENITE AND MONOMETHYL ARSONOUS ACID-INDUCED TOXICITY IN HUMAN UROTHELIAL CELLS. T. G. Bredfeldt 1 , K. E. Billings 1 , X. H. Zheng 1 , E. A. Mash 2 , F. E. Domann 3 , S. S. Lau 1 , D. A. Sens 4 and A. J. Gandolfi 1 . 1 Pharmacology and Toxicology, University of AZ, Tucson, AZ, 2 3 Chemistry, University of AZ, Tucson, AZ, Radiation Oncology, University of IA, Iowa City, IA and 4 Pathology and Surgery, University of ND, Grand Forks, ND. #148 METABOLISM AND TOXICITY OF ARSENIC IN HUMAN URINARY BLADDER EPITHELIAL CELLS EXPRESSING RAT ARSENIC (+3)- METHYLTRANSFERASE. Z. Drobna 1 , S. B. Waters 2 , V. Devesa 3 , A. W. Harmon 1 , D. J. Thomas 4 and M. Styblo 1,3 . 1 Pediatrics, UNC Chapel Hill, NC, Chapel Hill, NC, 2 Curriculum in Toxicology, UNC, Chapel Hill, NC, 3 CEMALB, UNC, Chapel Hill, NC and 4 NHEERL, U.S. EPA, Triangle Research Park, NC. #149 GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE (GAPDH) AS AN ARSENATE REDUCTASE IN HUMAN RED BLOOD CELLS (HRBC) AND RAT LIVER CYTOSOL (RLC). Z. Gregus and B. Nemeti. Department Pharmacology, University Pecs, Med. School, Pecs, Hungary. #150 ARSENITE INDUCES PROCOAGULANT ACTIVITY IN HUMAN PLATELETS BY PHOSPHATIDYLSERINE EXPOSURE AND MICROPARTICLE GENERATION. O. Bae, K. Lim and J. Chung. College of Pharmacy, Seoul National University, Seoul, South Korea. #151 ARSENIC METHYLTRANSFERASE CYT19 EXPRESSION AND ACTIVITY IN RAT TISSUES. Y. Kobayashi 1,2 , T. Hayakawa 1 and S. Hirano 1 . 1 Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan and 2 Japan Foundation for Aging and Health, Chita, Aichi, Japan. #152 THE ROLE OF VALENCE AND METHYLATION STATE ON THE ACTIVITY OF ARSENIC DURING MITOSIS. A. D. Kligerman, C. L. Doerr and A. H. Tennant. Environmental Carcinogenesis Division, U.S. EPA, Research Triangle Park, NC. Sponsor: D. Wolf. #153 INORGANIC ARSENIC BIOTRANSFORMATION AND MMA(V) REDUCTASE/GSTO1-1 KNOCKOUT MICE. U. K. Chowdhury, R. A. Zakharyan, M. D. Avram, M. Wollenberg, A. Hernandez, M. Kopplin and H. V. Aposhian. Molecular and Cellular Biology, University of Arizona, Tucson, AZ. #154 DETERMINATION OF TRANSCRIPTION FACTORS IMPORTANT IN ARSENIC-INDUCED ALTERATIONS IN GENE EXPRESSION. A. Hays 1 , R. Pandey 2 , R. Ahmed 1 , A. S. Andrew 3 , J. W. Hamilton 3 and C. Lantz 1 . 1 Cell Biology and Anatomy, University of Arizona, Tucson, AZ, 2 Arizona Cancer Center, University of Arizona, Tucson, AZ and 3 Pharmacology & Toxicology, Dartmouth Medical School, Hanover, NH. #155 ARSENIC IN SEAFOOD: WHAT PERCENTAGE OF THE TOTAL IS INORGANIC ARSENIC? L. L. Chappell 1 , J. Colman 1 , R. M. Lorenzana 3 , P. McGinnis 2 , R. Troast 4 and A. Yeow 4 . 1 Environ Sciences Ctr, Syracuse Research Corp, Syracuse, NY, 2 Syracuse Research Corp, Philadelphia, PA, 3 ORD Region 10, U.S. EPA, Seattle, WA and 4 OSRTI, U.S. EPA, Washington, DC. #156 ASSESSMENT OF EXPOSURE TO ARSENIC AND LIFE STYLE IN KOREAN. J. Park 1 , W. Lee 1 , M. Choi 4 , E. Park 2 , K. Park 3 and S. Kim 3 . 1 Preventive Medicine, Chung-Ang University, Seoul, South Korea, 2 Pathology, Chung-Ang University, Seoul, South Korea, 3 Advanced Analysis Center, Korea Institute of Science and Technology, Seoul, South Korea and 4 Chung-Un University, Chung-Un, South Korea. #157 URANYL ACETATE INDUCED OXIDATIVE STRESS IN CHINESE HAMSTER OVARY AA8 CELLS: EFFECT ON DNA OXIDATION. J. Orozco 1 , A. M. Hays 1 , M. Yazzie 2 , D. M. Stearns 2 and C. Lantz 1 . 1 Cell Biology and Anatomy, University of Arizona, Tucson, AZ and 2 Department of Chemistry and Biochemistry, Northern Arizona University, Flagstaff, AZ. #158 THE HPRT SPECTRA OF SPONTANEOUS, URANYL-ACETATE- AND HYDROGEN- PEROXIDE-INDUCED HPRT MUTANTS IN CHINESE HAMSTER OVARY EM9 CELLS. V. H. Coryell and D. M. Stearns. Chemistry and Biochemistry, Northern Arizona University, Flagstaff, AZ. 60 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #159 CYTOTOXICITY, GENOTOXICITYAND MUTAGENICITY OF COMBINED EXPOSURES OF URANYL ACETATE AND SODIUM ARSENITE IN CHO CELLS. Y. Monica 1 , W. H. Johnson 1 , J. T. Shelley 1 , H. M. Allison 2 , R. C. Lantz 2 and D. M. Stearns 1 . 1 Chemistry and Biochemistry, Northern Arizona University, Flagstaff, AZ and 2 Cell Biology and Anatomy, University of Arizona, Tucson, AZ. #160 GENOTOXICITY OF PARTICULATE URANIUM AND CHROMIUM. S. S. Wise 1,2 , A. L. Holmes 1,2 , J. A. Moreland 1,2 and J. P. Wise 1,2 . 1 Wise Laboratory of Environmental and Genetic Toxicology, University of Southern Maine, Portland, ME and 2 Maine Center for Toxicology and Environmental Health, University of Southern Maine, Portland, ME. #161 NEPHROTOXIC EFFECTS OF DEPLETED URANIUM (DU) IN THE RAT. INTERACTIONS WITH STRESS. L. Tobias 1 , D. Barber 2 , K. Zimmerman 1 , S. Hancock 1 , J. Hinckley 1 , M. Ehrich 1 and B. S. Jortner 1 . 1 Virginia Tech, Blacksburg, VA and 2 University of Florida, Gainesville, FL. #162 BIOLOGIC EFFECTS AFTER BRIEF INHALATION EXPOSURE TO URANIUM OXIDE OR DEPLETED URANIUM OXIDE AEROSOLS. F. F. Hahn 1 , E. B. Barr 1 , G. Bench 2 , J. Karlsson 3 and J. Lewis 3 . 1 Lovelace Respiratory Research Institute, Albuquerque, NM, 2 LLNL, Livermore, CA and 3 University of New Mexico, Albuquerque, NM. #163 RENAL BIOMARKER RESULTS IN DEPLETED URANIUM (DU) EXPOSED GULF WAR VETERANS. M. A. McDiarmid 1,2 and K. Squibb 1,2 . 1 Occupational Health, University of Maryland Medical Center, Baltimore, MD and 2 Depleted Uranium Followup Program, VA Maryland Health Care System, Baltimore, MD. #164 ASSESSING THE RENAL TOXICITY OF DEPLETED URANIUM AND OTHER URANIUM COMPOUNDS. L. E. Roszell 1 , F. F. Hahn 2 and R. B. Lee 1 . 1 US Army Center for Health Promotion and Preventive Medicine, Aberdeen Proving Ground, MD and 2 Lovelace Respiratory Research Institute, Albuquerque, NM. #165 UTILITY OF PATIENT MAILED URINE SPECIMENS FOR RENAL BIOMARKER ANALYSIS IN DEPLETED URANIUM (DU) EXPOSED 1991 GULF WAR VETERANS. K. S. Squibb 1,2 , M. Oliver 1,2 , P. Gucer 1,2 , S. Engelhardt 2,1 and M. McDiarmid 1,2 . 1 Program in Toxicology, University of Maryland School of Medicine, Baltimore, MD and 2 Depleted Uranium Program, VA Maryland Health Care System, Baltimore, MD. Monday Morning, March 7 9:30 AM to 12:30 PM Exhibit Hall POSTER SESSION: IMMUNOTOXICOLOGY–METHODS AND SAFETY EVALUATION Chairperson(s): Danuta Herzyk, GlaxoSmithKline, Safety Assessment Immunotoxicology, King of Prussia, PA and Kimber White, Virginia Commonwealth University, Pharmacology and Toxicology, Richmond, VA. Displayed: 9:30 AM–12:30 PM Attended: 9:30 AM–11:00 AM #166 NK CELL CYTOTOXICITY EVALUATION: TECHNICAL AND ANALYTICAL ALTERNATIVES TO CONVENTIONAL 51 1 CHROMIUM RELEASE ASSAY. E. R. Gore , J. K. Gower 1 , E. Kurail 2 and D. J. Herzyk 1 . 1 Safety Assessment, GlaxoSmithKline, King of Prussia, PA and 2 Statistical Sciences, GlaxoSmithKline, King of Prussia, PA. #167 ANTI-NKP46 IMPROVES DETECTION OF NATURAL KILLER CELLS IN MACAQUE BLOOD. W. Frings and G. Weinbauer. Covance Laboratories GmbH, 48163 Muenster, Germany. #168 IMMUNE SYSTEM DEVELOPMENT IN THE CYNOMOLGUS MONKEY: LYMPH NODES AND SPLEEN. G. Habermann, S. Friderichs-Gromoll, J. Kaspareit and E. Buse. Covance Laboratories GmbH, 48163 Muenster, Germany. Sponsor: G. Weinbauer. #169 ANALYTICAL VALIDATION OF PERIPHERAL BLOOD IMMUNOPHENOTYPING FOR CYNOMOLGUS MONKEY. R. Caldwell, J. Fishel, G. Leatherberry and P. Marshall. Covance Laboratories, Madison, WI. Sponsor: P. Thomas. #170 IMMUNOGENICITY AND IMMUNOTOXICITY ASSESSMENTS OF TWO DRUG AFFINITY COMPLEX COMPOUNDS IN CYNOMOLGUS MONKEYS. S. Wen 1 , V. Iordanova 1 , C. N. Papagiannis 2 , M. Rebelatto 2 , T. Najarian 1 and J. Castaigne 1 . 1 ConjuChem, Inc., Montreal, QC, Canada and 2 MPI Research, Inc., Mattawan, MI. Sponsor: J. Daniels. #171 DEVELOPMENT AND VALIDATION OF SEMI- QUANTITATIVE ASSAYS FOR TOTAL AND NEUTRALIZING PRIMATE ANTIBODIES AGAINST A HUMAN THERAPEUTIC MONOCLONAL ANTIBODY. X. Guo 1 , D. Finco- Kent 1 , C. Soderstrom 1 , B. Cohen 1 , H. Wang 1 and T. Kawabata 1 . 1 Pfizer Inc., Groton, CT and 2 Pfizer Inc., Groton, CT. #172 TEMPORAL STABILITY OF WHOLE BLOOD AND MONONUCLEAR CELL CULTURES TO SUPPORT LYMPHOCYTE PROLIFERATION FOLLOWING MITOGEN AND RECALL ANTIGEN STIMULATION. M. Wing, S. Wilkins, J. Hubbard and K. Gilbert. Huntingdon Life Sciences Ltd., Huntingdon, United Kingdom. Sponsor: S. Dean. MONDAY up-to-date information at www.toxicology.org 61
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Program - Society of Toxicology

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