Program - Society of Toxicology

44 th Annual Meeting
and ToxExpo
Program Description
WEDNESDAY
#1606 NECROSIS AND NOT APOPTOSIS IS THE
PREDOMINANT MODE OF CELL DEATH IN
MORTAL HUMAN PROXIMAL TUBULE CELLS
EXPOSED TO CADMIUM CHLORIDE. S. Somji 1 ,
S. H. Garrett 1 , M. Sens 1 and D. A. Sens 2 . 1 Pathology,
University of North Dakota, Grand Forks, ND and
2 Surgery, University of North Dakota, Grand Forks,
ND.
#1607 CADMIUM-INDUCED CELL CYCLE ARREST IN
RAT KIDNEY EPITHELIAL CELLS IS
MEDIATED THROUGH P53 ACTIVATION. J. Xie
and Z. A. Shaikh. Department of Biomedical and
Pharmaceutical Science, University of Rhode Island,
Kingston, RI.
#1608 CADMIUM-INDUCED CARCINOGENIC
TRANSFORMATION OF HUMAN PANCREATIC
DUCTAL CELLS. W. Qu 1 , B. Diwan 2 , D. Broderick 1 ,
M. Tsao 3 and M. Waalkes 1 . 1 Laboratory of Comparative
Carcinogenesis, NCI at NIEHS, Research Triangle Park,
NC, 2 BRP, SAIC-Frederick, NCI at Frederick,
Frederick, MD and 3 Ontario Cancer Institute, Toronto,
ON, Canada.
#1609 CADMIUM MAY AFFECT THE LIGAND
INDUCED MIGRATORY ABILITY OF
IMMORTALIZED EXTRAVILLOUS
TROPHOBLAST CELLS. M. M. Alvarez and C.
Chakraborty. Pathology, University of Western Ontario,
London, ON, Canada. Sponsor: M. Cherian.
#1610 CHRONIC EXPOSURE TO CADMIUM INDUCES
ANEMIA WITH HIGH IRON STORAGE
THROUGH DEFECTIVE IRON UTILIZATION
AND ENHANCED IRON ABSORPTION IN RATS.
H. Horiguchi, E. Oguma, H. Uno and F. Kayama. Jichi
Medical School, Tochigi, Japan. Sponsor: T. Yoshida.
#1611 BEHAVIORAL ALTERATIONS OF C57BL AND
METALLOTHIONEIN KNOCK-OUT MICE
PERINATALLY EXPOSED TO LOW LEVEL OF
CADMIUM. C. Watanabe 1 , A. Watanabe 1 , M. Satoh 2 ,
K. Yoshida 3 , K. Mori 3 , H. Ishitobi 1 and A. Honda 2 .
1 Human Ecology, University of Tokyo, Tokyo, Japan,
2 Hygienics, Gifu Pharmaceutical University, Gifu, Japan
and 3 Endocrinology, Tohoku University School of
Medicine, Sendai, Japan.
#1612 MODULATION OF ACUTE HEPATOTOXICITY
OF CADMIUM BY SIMULTANEOUS
ADMINISTRATION OF COBALT IN MICE. S.
Himeno. Fac. of Pharmaceutical Sciences, Tokushima
Bunri University, Tokushima, Japan. Sponsor: M. Sato.
#1613 LIVER INJURY IN METALLOTHIONEIN-NULL
MICE AFTER TREATMENT WITH
THIOACETAMIDE. S. Jiang and G. M. CHERIAN.
Pathology, University.of Western Ont, London, ON,
Canada.
#1614 THE NORMAL HUMAN PROSTATE
EPITHELIAL CELL LINE, RWPE-1, AS AN IN
VITRO MODEL SYSTEM OF
METALLOTHIONEIN REGULATION IN THE
PROSTATE. R. K. Singh 1 , S. Somji 1 , M. Sens 1 , D. A.
Sens 2 and S. H. Garrett 1 . 1 Pathology, University of
North Dakota, Grand Forks, ND and 2 Surgery,
University of North Dakota, Grand Forks, ND.
#1615 METALLOTHIONEIN SUSTAINS
METALLOPROTEINASE2 GENE EXPRESSION
IN IMMORTALIZED FIBROBLAST CELLS. M.
Takiguchi 1,2 , M. Higashimoto 2 , S. Suzuki 2 , S.
Yoshihara 1 and M. Sato 2 . 1 Faculty of Pharmaceutical
Sciences, Hiroshima International University, Kure,
Hiroshima, Japan and 2 Faculty of Pharmaceutical
Sciences, Tokushima Bunri University, Tokushima,
Japan.
#1616 POST-TRANSLATIONAL STABILIZATION OF
METALLOTHIONEIN ISOFORM 3 IN THE
NORMAL BLADDER CELL LINE, UROTSA. D. A.
Sens 1 , S. Somji 2 , R. Singh 2 , M. Sens 2 and S. H. Garrett 2 .
1 Surgery, University of North Dakota, Grand Forks, ND
and 2 Pathology, University of North Dakota, Grand
Forks, ND.
#1617 ACTIVITY OF METAL-RESPONSIVE
TRANSCRIPTION FACTOR 1 IS MODULATED
BY METALLOTHIONEIN. T. Kimura 1 , N. Itoh 2 , T.
Sone 1 , M. Isobe 1 and K. Tanaka 2 . 1 Department of
Toxicology, Faculty of Pharmaceutical Sciences,
Setsunan University, Hirakata, Japan and 2 Department
of Toxicology, Graduate school of Pharmaceutical
Sciences, Osaka University, Suita, Japan.
#1618 THE EFFECT OF METALLOTHIONEIN
ISOFORM-3 MUTANTS ON THE
DIFFERENTIATION OF BREAST CANCER MCF-
7 CELLS. M. Sens 1 , S. H. Garrett 1 , S. Somji 1 and D. A.
Sens 2 . 1 Pathology, University of North Dakota, Grand
Forks, ND and 2 Surgery, University of North Dakota,
Grand Forks, ND.
#1619 PRODUCTION OF METALLOTHIONEIN
POLYCLONAL ANTIBODIES USING CHICHENS
AS MODEL. E. Brambila 1 , A. Ortiz/Bueno 1 , B. Leon-
Chavez 1 , W. Achanzar 2 and M. P. Waalkes 2 . 1 Clinical
Chemistry, Benemerita Universidad Autonoma de
Puebla, Puebla, Mexico and 2 NIH, Research Triangle
Park, NC.
Wednesday Morning, March 9
9:30 AM to 12:30 PM
Exhibit Hall
POSTER SESSION: IN VITRO
Chairperson(s): Mohamed Abou-Donia, Duke University, Durham, NC and
Bhupendra Kaphalia, University Of Texas, Galveston, TX.
Displayed: 9:30 AM–12:30 PM
Attended: 9:30 AM–11:00 AM
#1620 INTERACTION OF PB AND DEET, ALONE AND
IN COMBINATION WITH P-GLYCOPROTEIN
EXPRESSED IN E. COLI LEAKY MUTANT. E. M.
El-Masry and M. B. Abou-Donia. Pharmacology and
Cancer Biology, Duke University Medical Center,
Durham, NC.
#1621 HORMESIS EFFECT OF TRACE METALS ON
CULTURED NORMAL AND IMMORTAL HUMAN
MAMMARY CELLS. C. N. Cheng, A. Marino, C. M.
Schmidt, R. Konsoula and F. A. Barile. Pharmaceutical
Sciences, St. John’s University College of Pharmacy,
Jamaica, NY.
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SOT’s 44 th Annual Meeting