Program - Society of Toxicology

44 th Annual Meeting
and ToxExpo
Program Description
#1528 THROMBIN PRECONDITIONING PREVENTS
STRIATAL ATROPHY AND DOPAMINERGIC
TERMINAL LOSS, BUT NOT DOPAMINE
DEPLETION IN A 6−HYDROXYDOPAMINE
PARKINSON′S DISEASE MODEL. J. R. Cannon 1,2 ,
Y. Hua 1 , G. Xi 1 and R. F. Keep 1,3 . 1 Department of
Neurosurgery, The University of Michigan, Ann Arbor,
MI, 2 Department of Envrionmental health Sciences, The
University of Michigan, Ann Arbor, MI and
3 Department of Physiology, The University of
Michigan, Ann Arbor, MI.
#1529 ROLE FOR PROTEASE-ACTIVATED
RECEPTOR 1 (PAR1) IN MPTP-INDUCED
DOPAMINERGIC NEUROTOXICITY. C. Hamill 1 ,
M. Caudle 2 , J. R. Richardson 2 , G. W. Miller 2 and S. F.
Traynelis 1 . 1 Department of Pharmacology, Emory
University, Atlanta, GA and 2 Center for
Neurodegenerative Disease, Emory University, Atlanta,
GA.
#1530 NICOTINE STIMULATION INDUCES TH
MESSENGER RNA EXPRESSION AND
TRANSCRIPTION RATE IN MN9D CELLS. P. M.
Radcliffe 1 and A. Tank 2 . 1 Toxicology, University of
Rochester, Rochester, NY and
2 Pharmacology/Physiology, Univer of Rochester,
Rochester, NY.
#1531 NEUROPROTECTION AND NEURORESCUE
AGAINST BETA-AMYLOID TOXICITY BY
METALLOTHIONEIN III. C. Choi 3 , Y. Hwang 1,2 , D.
Oh 1,2 , D. Shin 1,2 , J. Choi 1,2 , D. Kim 4 and H. Jeong 1,2 .
1 Pharmacy, Chosun University, Kwangju, South Korea,
2 Research Center for Proteineous Materials, Chosun
University, Kwangju, South Korea, 3 Division of Food
Science, Chinju International University, Chinju, South
Korea and 4 Pathology, College of Oriental Medicine,
Daejeon University, Daejeon, South Korea.
#1532 CHARACTERIZATION OF CEREBRAL SP1, Aβ
AND APP IN RATS: AN
IMMUNOHISTOCHEMICAL STUDY OF AGING
AND NEURODEGENERATION. B. Brock, K.
DiPalma, M. Basha and N. H. Zawia. Biomediacl and
Pharmaceutical Sciences, University of Rhode Island,
Kingston, RI.
#1533 THE CHOROID PLEXUS EXPRESSES THE
ENZYMES NECESSARY FOR BETA-AMYLOID
PRODUCTION. E. L. Smith, J. S. Crossgrove and W.
Zheng. School of Health Sciences, Purdue University,
West Lafayette, IN.
#1534 THE CHOROID PLEXUS ACCUMULATES BETA-
AMYLOID FROM BRAIN CSF: IMPLICATIONS
FOR ALZHEIMER’S DISEASE. J. S. Crossgrove, G.
Li and W. Zheng. School of Health Sciences, Purdue
University, West Lafayette, IN.
#1535 DIFFERENTIAL EXPRESSION OF GRP78 AND
HSP70 IN PRIMARY BRAINSTEM AND
CORTICAL ASTROCYTES EXPOSED TO 1, 3-
DINTROBENZENE. S. A. Runkle, S. R. Steiner and
M. A. Philbert. Toxicology Program, University of
Michigan, Ann Arbor, MI.
#1536 MIXED INHIBITION OF THE PYRUVATE
DEHYDROGENASE COMPLEX BY M-
DINITROBENZENE. J. A. Miller and M. A. Philbert.
Toxicology Program, University of Michigan, Ann
Arbor, MI.
#1537 NITRIC OXIDE MEDIATES MITOCHONDRIAL
DYSFUNCTION IN NEUROENDOCRINE
TOXICITY. D. E. Heck 1,2 , J. Gray 1 , D. Osbourn 2 and
P. J. Smith 2 . 1 Rutgers University, Piscataway, NJ and
2 Marine Biological Laboratory, Woods Hole, MA.
#1538 NITRIC OXIDE ACTIVATES P53 AND INDUCES
APOPTOSIS IN NEURONAL PC12 CELLS. C.
Brynczka 1,2 and A. Merrick 1 . 1 National Center For
Toxicogenomics, NIEHS, Research Triangle Park, NC
and 2 Environmental and Molecular Toxicology, NCSU,
Raleigh, NC.
#1539 EVALUATION OF THE INTERACTION
BETWEEN CAVEOLIN AND GLIAL
FIBRILLARY ACIDIC PROTEIN IN C6 GLIA. G.
Velazquez 1 , E. E. Aquino 1 , N. Mayol 2 , H. Maldonado 2
and W. I. Silva 1 . 1 Physiology, UPR Medical Sciences
Campus, San Juan, Puerto Rico and 2 Pharmacology,
Caribbean Central University, Bayamon, Puerto Rico.
Sponsor: B. Jimenez Velez.
#1540 REACTIVE GLIOSIS IN NEUROTOXIC AND
MECHANICAL INJURY MODELS. C. L. Damiani,
D. B. Miller and J. P. O’Callaghan. CDC-NIOSH,
Morgantown, WV.
#1541 ERK1/2-RSK2 STIMULATION OF MEF2C
TRANSCRIPTION PROMOTES CORTICAL
NEURON SURVIVAL. Y. Wang, L. Liu and Z. Xia.
Environmental and Occupational Health Sciences,
University of Washington, Seattle, WA.
#1542 DEVELOPMENTAL LEAD EXPOSURE AFFECTS
THE SURVIVAL OF GRANULE CELLS IN THE
RAT HIPPOCAMPUS. T. Verina, C. A. Rohde and T.
R. Guilarte. Environmental Health Sciences, Johns
Hopkins University, Baltimore, MD.
#1543 PPAR ALPHA ACTIVATION ENHANCES
CYANIDE-INDUCED NEUROTOXICITY BY UP-
REGULATION OF UCP-2. X. Zhang, L. Li, K.
Prabhakaran, J. L. Borowitz and G. E. Isom. Medicinal
Chemistry and Molecular Pharmacology, Purdue
University, West Lafayette, IN.
#1544 NEUROPROTECTION AGAINST
METHAMPHETAMINE (METH) AFFORDED BY
PRETREATMENT WITH INCREASING DOSES
OF THE DRUG IS DEPENDENT ON THE
DOSING SCHEDULE OF METH USED DURING
THE DRUG CHALLENGE. D. L. Graham 1,2 , P. H.
Noailles 1 , B. Ladenheim 1 , T. H. Moran 3 and J. L.
Cadet 1 . 1 Molecular Neuropsychiatry Branch,
DHHS/NIH/NIDA/IRP, Baltimore, MD, 2 Program in
Toxicology, University of Maryland School of
Medicine, Baltimore, MD and 3 Department of
Psychiatry and Behavioral Sciences, The Johns Hopkins
University School of Medicine, Baltimore, MD.
WEDNESDAY
up-to-date information at www.toxicology.org 167