infertility treatments, genes and chromosomes

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PGS- the controversy • It is widely accepted that PGS reduces the risk of Down syndrome BUT… • Several randomised trials have shown no improvement in pregnancy rates
Increase in implantation/pregnancy‐ controversy • Mastenbroek et al (2007), NEJM • Maternal age >35 • 8 chromosomes assessed, randomised • No significant improvement in implantation
Page 1 and 2: In vitro fertilisation and genetic
Page 3 and 4: Indications for IVF/ICSI Unexplaine
Page 5 and 6: Egg collection procedure
Page 7 and 8: Fertilization Mixing of sperm and e
Page 9 and 10: Embryo development 2‐cell embryo
Page 11 and 12: Genetic analysis of embryos
Page 13 and 14: Aneuploidy and IVF failure Chromoso
Page 15: Preimplantation genetic screening (
Page 19 and 20: Problems with negative PGS studies
Page 21 and 22: Microarray comparative genomic hybr
Page 23 and 24: 46,XX‐10 +16 Microarray‐CGH (ar
Page 25 and 26: Blastocyst CGH‐ clinical results
Page 27 and 28: PGD of single gene disorders Altern
Page 29 and 30: PGD of single gene disorders Diseas
Page 31 and 32: Cleavage stage biopsy •Used by ma
Page 33 and 34: Generalized Diagnostic Methodology

infertility treatments, genes and chromosomes

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