infertility treatments, genes and chromosomes

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Infertility • Unprotected intercourse for 1 year without conception • Very common – 1 in 6 couples affected • In vitro fertilization first birth in 1978 • More than 3,000,000 IVF babies worldwide • 1‐5% of all births in Western countries
Indications for IVF/ICSI Unexplained 9% Other 9% Uterine 2% Male 27% Anovulation 12% Endometriosis 15% Tubal 26%
Page 1: In vitro fertilisation and genetic
Page 5 and 6: Egg collection procedure
Page 7 and 8: Fertilization Mixing of sperm and e
Page 9 and 10: Embryo development 2‐cell embryo
Page 11 and 12: Genetic analysis of embryos
Page 13 and 14: Aneuploidy and IVF failure Chromoso
Page 15 and 16: Preimplantation genetic screening (
Page 17 and 18: Increase in implantation/pregnancy
Page 19 and 20: Problems with negative PGS studies
Page 21 and 22: Microarray comparative genomic hybr
Page 23 and 24: 46,XX‐10 +16 Microarray‐CGH (ar
Page 25 and 26: Blastocyst CGH‐ clinical results
Page 27 and 28: PGD of single gene disorders Altern
Page 29 and 30: PGD of single gene disorders Diseas
Page 31 and 32: Cleavage stage biopsy •Used by ma
Page 33 and 34: Generalized Diagnostic Methodology

infertility treatments, genes and chromosomes

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