infertility treatments, genes and chromosomes

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Microarray comparative genomic hybridization • Rapid –results in 24 hours • Allows the copy number of every chromosome to be determined d Embryo DNA Normal DNA Trisomy Monosomy Normal Gutierrez‐Mateo et al., 2010; Fragouli et al., 2010
46,XX‐10 +16 Microarray‐CGH (array‐CGH or aCGH)
Page 1 and 2: In vitro fertilisation and genetic
Page 3 and 4: Indications for IVF/ICSI Unexplaine
Page 5 and 6: Egg collection procedure
Page 7 and 8: Fertilization Mixing of sperm and e
Page 9 and 10: Embryo development 2‐cell embryo
Page 11 and 12: Genetic analysis of embryos
Page 13 and 14: Aneuploidy and IVF failure Chromoso
Page 15 and 16: Preimplantation genetic screening (
Page 17 and 18: Increase in implantation/pregnancy
Page 19 and 20: Problems with negative PGS studies
Page 21: Microarray comparative genomic hybr
Page 25 and 26: Blastocyst CGH‐ clinical results
Page 27 and 28: PGD of single gene disorders Altern
Page 29 and 30: PGD of single gene disorders Diseas
Page 31 and 32: Cleavage stage biopsy •Used by ma
Page 33 and 34: Generalized Diagnostic Methodology

infertility treatments, genes and chromosomes

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