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6 APPLICATION DR. DINA GROHMANN FUNDING ID Year Funding Body Project Title Time period Amount 2009 Bogue Foundation (UK) Research Fellowship Jul – Aug 2012 4 500 £ 2010 Wellcome Trust (UK) Postdoctoral stipend 2011 - 2012 33 035 £ 2012 Deutsche Forschungsgemeinschaft (D) 2013 German Israel Foundation (D) 2013 Fonds der Chemischen Industrie (D) 2013 Boehringer-Ingelheim- Stiftung Dynamics and Mechanisms of Argonaute proteins Single molecule analysis of transcription complex dynamics Sachkostenzuschuss für den Hochschullehrernachwuchs Protein-based scaffolding of nanostructures Apr 2012 - 2015 422 858 € Jan – Dec 2013 34 000 € 2013 – 2016 10 000 € pending
7 APPLICATION DR. DINA GROHMANN RESEARCH OBJECTIVES Biological machines are multisubunit macromolecular complexes that drive cellular functions in a highly efficient and specific manner. Molecular machines are functional units that spontaneously form in a cellular environment with correct stoichiometry and a preserved architecture to ensure full activity. Over the last two decades – aiming to imitate efficient biological machineries – artificial nanostructures have been developed that form defined 2D- and 3D-shapes including carbonnanotubes, DNA Origami and cyclodextrins. Among these, DNA Origami found a remarkable rise of interest spurred by its exceptional properties to allow a precise and accurate arrangement of functional molecules like proteins, nanoparticles, DNA “docking stations” for biomolecular assays and fluorescent probes. These Origami structures are based on a ‘scaffold’ DNA strand (the singlestranded DNA genome of bacteriophage M13), which can be folded into pre-defined 2D and 3D assemblies at the nanometre scale with the help of hundreds of short oligonucleotides called ‘staple strands’. Research in my group exploits the knowledge we gain from studying biological machineries to build new functional nanostructures. The detailed characterization of complex biological systems is still a challenge and therefore I use an interdisciplinary approach to reach a comprehensive picture of cellular machineries. My research is focused on two cellular machineries involved in RNA production and posttranscriptional regulation, the transcriptional apparatus and the RNA induced silencing complex (RISC). My lab combines classical biochemical methods with sophisticated biophysical techniques (e.g. single molecule fluorescence spectroscopy and electron paramagnetic resonance spectroscopy) and chemical biology. I have a long-standing expertise in the chemical modification of biomolecules which allows me to site-specific incorporate labels like fluorescent dyes or spin labels into the biomolecules in order to allow biophysical studies and to build new functional materials based on these biomolecules. To this end, I work on the extension of the chemical toolkit to provide new labelling strategies and functional molecules. Biology, Biophysics, Chemical Biology and Nanotechnology are essential ingredients for my long-term project that aims to develop biosensors and nanomaterials (“lab on a chip”). Ideally, these sensors allow a sensitive measurement of cellular parameters that can be quantified via single molecule measurements.
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