von Willebrand Disease Presentation - Virginia Commonwealth ...

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Spontaneous Mutation • Change in gene occurs during prenatal development (in womb before birth) • Occurs when neither parent has vWD • Future inheritance pattern will be the same as in someone with a family history of vWD Montgomery RR, Hilgartner MW. Understanding von Willebrand Disease. New York, NY: National Hemophilia Foundation; 1991.
Diagnosis of vWD • Personal and family history of bleeding symptoms • Blood work to check von Willebrand levels and type • Type 1 disease often diagnosed later in life after extensive dental work or heavy menses. • Often adult parent diagnosed after child found to have the disease
Page 1 and 2: Von Willebrand Disease: When is a
Page 3 and 4: Objectives • To review the clinic
Page 5 and 6: von Willebrand Disease (vWD) A pers
Page 7 and 8: Clotting Illustration William J. A
Page 9: Platelet Plug Formation • Platele
Page 12 and 13: Prevalence of vWD • Most common i
Page 14 and 15: Type 1 vWD • Most common type; in
Page 16: • Rare Type 3 vWD • Quantitativ
Page 19 and 20: vWD: Sites of Bleeding Mucous membr
Page 21 and 22: Symptoms of vWD • Bleeding after
Page 23 and 24: Characteristics of Menorrhagia •
Page 27 and 28: Causes of variance in Von Willebran
Page 29 and 30: Inheritance of vWD • Gene is carr
Page 31: Inheritance Pattern by Type of von
Page 35 and 36: Suggested Questions for Screening P
Page 37 and 38: Suggested Questions for Screening P
Page 39 and 40: Treatment of vWD • Treatment deci
Page 41 and 42: Intranasal Desmopressin: Stimate
Page 43 and 44: Side-effects of Stimate • Fluid r
Page 45 and 46: Amicar (aminocaproic acid) • Oral
Page 47 and 48: Hormonal Therapy for vWD • Treatm
Page 49 and 50: Treatment With vWF Concentrates (co
Page 51 and 52: Psychosocial Issues: Adolescent Wom
Page 53 and 54: Recommendations for Patients • Ha
Page 55 and 56: Summary • In VWD, you either have
Page 57 and 58: Summary • Treatments for VWD incl
Page 59 and 60: Referral for evaluation of VWD •
Page 61 and 62: Role of Hemophilia Treatment Center
Page 63: Virginia Bleeding Disorders Program

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