Apheresis: Basic Principles, Practical Considerations and

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Use of <strong>Apheresis</strong> • Donor - facilitate collection of a blood component from an allogeneic donor: Platelets, Granulocytes, source plasma, HPC collection • Therapy (therapeutic apheresis): *removing undesired substances like antibodies, lipids *reducing excess WBC/Platelets *automated exchange of sickled RBC *HPC collection
Use of <strong>Apheresis</strong> (cont.) Therapeutic apheresis assures the immediate removal of abnormal substances from the circulation, which are either: *present in plasma *or tightly bound to plasma proteins
Page 1 and 2: Apheresis: Basic Principles, Practi
Page 3: Objectives (Part 2) • Clinical ap
Page 6 and 7: Apheresis- Mechanism of Action •L
Page 8 and 9: Separate blood components is based
Page 10 and 11: Apheresis- Mechanism of Action
Page 12 and 13: Plasmapheresis/TPE: Fluid Dynamics
Page 15: Technology •Automated centrifugal
Page 19 and 20: Apheresis Procedural Elements (+ Pr
Page 21 and 22: Venous Access *Apheresis require la
Page 25 and 26: Replacement Fluid *The primary func
Page 27 and 28: Comparison of Replacement Fluids Re
Page 31 and 32: Volume of Patient Plasma Exchanged
Page 33 and 34: Normal/abnormal Constituents Remove
Page 37 and 38: Anticoagulation
Page 39 and 40: Patient History and Medications •
Page 41 and 42: ACE inhibitors A.C.E. Inhibitor Ang
Page 45 and 46: Interval between Exchanges : Why we
Page 47 and 48: Complications 1) Hypotension S/S: l
Page 49 and 50: 4) Allergic reaction: Complications
Page 51 and 52: Journal of Clinical Apheresis 16:3,
Page 53 and 54: Blood/Plasma Volume Calculations
Page 55 and 56: TBV - Nadler’s Formula
Page 57 and 58: Estimated Blood Volume
Page 59 and 60: Treatment Dosage A “typical” or
Page 61 and 62: Hematopoietic Stem Cells Transplant
Page 63 and 64: HSCs Quantification: Why CD34 CD34
Page 65 and 66: In Steady State • HPCs circulatin
Page 67 and 68:
Mobilization of PBSCs Hematopoieti
Page 69 and 70:
Hematopoietic Growth Factors - CD34
Page 71 and 72:
Hematopoietic Growth Factors - CD34
Page 73 and 74:
HPC Collections -Technical Aspects
Page 75 and 76:
Post Collection Donor Issues • Pl
Page 77:
Post Collection Donor Issues G-CSF
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Apheresis: Basic Principles, Practical Considerations and

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