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Apheresis: Basic Principles, Practical Considerations and

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Interval between Exchanges : Why we do what we do...<br />

Alteration in Blood Constituents by a 1- PV Exchange<br />

Constituent % decrease % recovery<br />

48 hrs post exchange<br />

Clotting factors 25 – 50 80 – 100<br />

Fibrinogen 63 65<br />

Immuneglobulins 63 45<br />

Paraproteins 20 – 30 Variable<br />

Liver Enzymes 55 – 60 100<br />

Bilirubin 45 100<br />

C3 63 60 – 100<br />

Platelets 25 – 30 75 – 100<br />

Modified from : Weinstein, in McLeod, <strong>Apheresis</strong>, <strong>Principles</strong> <strong>and</strong> Practice, 3rd edition, AABB press, 2010

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