Apheresis: Basic Principles, Practical Considerations and

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HPC Collection Technichal Aspects- Guide
Post Collection Donor Issues • Platelets – Each collection, a donor loses ~4x10 11 plt – Plt count 30% (in product + G-CSF suppression) – After 2 collections, plt 2 days return to normal 7-10 days post collection pre-donation baseline by 1 year post donation – Donors with low platelet counts are at potential risk from bleeding <strong>and</strong> remain at risk for up to 1 week Miller, BBMT 2008; Tassi BMT 2005
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Apheresis: Basic Principles, Practi
Page 3:
Objectives (Part 2) • Clinical ap
Page 6 and 7:
Apheresis- Mechanism of Action •L
Page 8 and 9:
Separate blood components is based
Page 10 and 11:
Apheresis- Mechanism of Action
Page 12 and 13:
Plasmapheresis/TPE: Fluid Dynamics
Page 15 and 16:
Technology •Automated centrifugal
Page 17 and 18:
Use of Apheresis (cont.) Therapeuti
Page 19 and 20:
Apheresis Procedural Elements (+ Pr
Page 21 and 22:
Venous Access *Apheresis require la
Page 23 and 24: Apheresis Procedural Elements (+ Pr
Page 25 and 26: Replacement Fluid *The primary func
Page 27 and 28: Comparison of Replacement Fluids Re
Page 31 and 32: Volume of Patient Plasma Exchanged
Page 33 and 34: Normal/abnormal Constituents Remove
Page 37 and 38: Anticoagulation
Page 39 and 40: Patient History and Medications •
Page 41 and 42: ACE inhibitors A.C.E. Inhibitor Ang
Page 45 and 46: Interval between Exchanges : Why we
Page 47 and 48: Complications 1) Hypotension S/S: l
Page 49 and 50: 4) Allergic reaction: Complications
Page 51 and 52: Journal of Clinical Apheresis 16:3,
Page 53 and 54: Blood/Plasma Volume Calculations
Page 55 and 56: TBV - Nadler’s Formula
Page 57 and 58: Estimated Blood Volume
Page 59 and 60: Treatment Dosage A “typical” or
Page 61 and 62: Hematopoietic Stem Cells Transplant
Page 63 and 64: HSCs Quantification: Why CD34 CD34
Page 65 and 66: In Steady State • HPCs circulatin
Page 67 and 68: Mobilization of PBSCs Hematopoieti
Page 69 and 70: Hematopoietic Growth Factors - CD34
Page 71 and 72: Hematopoietic Growth Factors - CD34
Page 73: HPC Collections -Technical Aspects
Page 77: Post Collection Donor Issues G-CSF
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