Nav1.5 on IonWorks HT - Molecular Devices

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<strong>Nav1.5</strong> on IonWorks HT: Use-Dependent Block of <strong>Nav1.5</strong> First Pulse 8 th Pulse 33.3µM compound A
<strong>Nav1.5</strong> on IonWorks HT: State-Dependent Block of <strong>Nav1.5</strong> Normalized Current 1.0 0.5 0.0 n=9 -150 -100 -50 V Pre (mV) % current 160 140 120 100 80 60 40 20 0 0.001 0.01 0.1 1 10 100 1000 uM IC50 = 30.1µM ambroxol, V H = -150mV % current 160 140 120 100 80 60 40 20 0 0.001 0.01 0.1 1 10 100 1000 uM IC50 = 11.4µM ambroxol, V H = -100mV V H = -150mV vs. V H = -100mV
Page 1 and 2: Compound Screening against Cardiac
Page 3 and 4: Voltage-gated Na + (Nav) Channels a
Page 5 and 6: RT4-B8 Has Endogenously Expressed <
Page 7 and 8: RT4-B8 Na Current Electrophysiology
Page 9 and 10: IonWorks HT: An Automated E-phys Pl
Page 11 and 12: Nav1.5 on IonWorks
Page 15 and 16: I-V Curve: IonWorks HT vs Patch-cla
Page 19 and 20: Example Current Traces for Compound
Page 21: IC 50 Measurement: Correlation betw
Page 25: Acknowledgements n Wyeth Research (

Nav1.5 on IonWorks HT - Molecular Devices

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