Nav1.5 on IonWorks HT - Molecular Devices
Nav1.5 on IonWorks HT - Molecular Devices
Nav1.5 on IonWorks HT - Molecular Devices
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Voltage-gated Na + (Nav) Channels are<br />
<strong>Molecular</strong> Targets for Various Indicati<strong>on</strong>s<br />
n Na + influx generates and propagates acti<strong>on</strong> potentials<br />
n Modulati<strong>on</strong> of Na + current affects AP in excitable cells<br />
n Nav channel blockers have been used for various<br />
indicati<strong>on</strong>s<br />
- Including local anesthetics, antiarrhythmics, antic<strong>on</strong>vulsants, and<br />
antidepressant<br />
- N<strong>on</strong>-selectivity am<strong>on</strong>g Nav channels causes adverse side effects<br />
n Need selectivity for validated Nav channel targets<br />
- avoiding cardiac Nav channel(s) for safety
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