Nav1.5 on IonWorks HT - Molecular Devices
Nav1.5 on IonWorks HT - Molecular Devices
Nav1.5 on IonWorks HT - Molecular Devices
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<str<strong>on</strong>g>Nav1.5</str<strong>on</strong>g> <strong>on</strong> I<strong>on</strong>Works <strong>HT</strong>:<br />
State-Dependent Block of <str<strong>on</strong>g>Nav1.5</str<strong>on</strong>g><br />
Normalized Current<br />
1.0<br />
0.5<br />
0.0<br />
n=9<br />
-150 -100 -50<br />
V Pre<br />
(mV)<br />
% current<br />
160<br />
140<br />
120<br />
100<br />
80<br />
60<br />
40<br />
20<br />
0<br />
0.001 0.01 0.1 1 10 100 1000<br />
uM<br />
IC50 = 30.1µM ambroxol, V H = -150mV<br />
% current<br />
160<br />
140<br />
120<br />
100<br />
80<br />
60<br />
40<br />
20<br />
0<br />
0.001 0.01 0.1 1 10 100 1000<br />
uM<br />
IC50 = 11.4µM ambroxol, V H = -100mV<br />
V H = -150mV vs. V H = -100mV
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