Nav1.5 on IonWorks HT - Molecular Devices

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Family of Nav Channels Yu and Catterall, 2003 Heart nM TTX-resistant Catterall et al, 2003
RT4-B8 Has Endogenously Expressed <strong>Nav1.5</strong> Northern Blot: n n n Source: derived from a multipotent stem cell line, RT4-AC, which originated from a rat peripheral neurotumor Overall sequence identity between r<strong>Nav1.5</strong> and h<strong>Nav1.5</strong>: 94.2% Sequence identity within fourrepeat area: 98.9% Zeng, et al, 1996
Page 1 and 2: Compound Screening against Cardiac
Page 3: Voltage-gated Na + (Nav) Channels a
Page 7 and 8: RT4-B8 Na Current Electrophysiology
Page 9 and 10: IonWorks HT: An Automated E-phys Pl
Page 11 and 12: Nav1.5 on IonWorks
Page 15 and 16: I-V Curve: IonWorks HT vs Patch-cla
Page 19 and 20: Example Current Traces for Compound
Page 21 and 22: IC 50 Measurement: Correlation betw
Page 25: Acknowledgements n Wyeth Research (

Nav1.5 on IonWorks HT - Molecular Devices

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