National Collaborating Centre for Women's and Children's Health
National Collaborating Centre for Women's and Children's Health
National Collaborating Centre for Women's and Children's Health
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Intrathecal baclofen<br />
series (a follow-up to the previous RCT) reported deterioration in GMFM-A at 12 months after starting<br />
CITB when compared with baseline, but the difference was not statistically significant. (VERY LOW)<br />
One parallel RCT reported that, compared with baseline, there was a statistically significant<br />
improvement in GMFM-B (sitting) at 6 months in children <strong>and</strong> young people who received CITB <strong>and</strong><br />
st<strong>and</strong>ard treatment compared with those who received st<strong>and</strong>ard treatment alone. (MODERATE) One<br />
prospective case series (a follow-up to the previous RCT) reported a statistically significant<br />
improvement in GMFM-B functioning at 12 months after starting CITB when compared with baseline.<br />
(VERY LOW)<br />
One parallel RCT reported that, compared with baseline, there was a greater improvement in<br />
functioning (GMFM goal dimension score) at 6 months in children <strong>and</strong> young people who received<br />
CITB <strong>and</strong> st<strong>and</strong>ard treatment compared with those who received st<strong>and</strong>ard treatment alone, although<br />
the difference between the treatment groups was not statistically significant. (MODERATE) One<br />
prospective case series (a follow-up to the previous RCT) reported a statistically significant<br />
improvement in functioning (GMFM goal dimension score) at 12 months after starting CITB when<br />
compared with baseline. (VERY LOW)<br />
With regard to optimisation function measured using the Pediatric Evaluation of Disability Inventory<br />
(PEDI), one parallel RCT reported that, compared with baseline, there was no change in functional<br />
skills (PEDI functional skills overall scores) in children <strong>and</strong> young people treated with CITB <strong>and</strong><br />
st<strong>and</strong>ard treatment or in those treated with st<strong>and</strong>ard treatment alone <strong>and</strong> that comparison of these<br />
findings across the treatment groups was not statistically significant. (MODERATE) One prospective<br />
case series (a follow-up to the previous RCT) reported that, compared with baseline, there was no<br />
statistically significant change in functional skills (PEDI functional skills overall scores) at 12 months<br />
after starting CITB. (VERY LOW)<br />
One prospective case series reported that, compared with baseline, in children <strong>and</strong> young people who<br />
received CITB implantation there was deterioration in self-care functioning (PEDI functional skills<br />
scale, self-care domain) at 6 months that was not statistically significant, but there was a statistically<br />
significant improvement at 18 months. (VERY LOW) Another prospective case series reported a<br />
statistically significant improvement (compared with baseline) in self-care functioning (PEDI functional<br />
skills scale, self-care domain) at 12 months in children <strong>and</strong> young people who received CITB. (VERY<br />
LOW)<br />
One prospective case series reported that in children <strong>and</strong> young people who received CITB,<br />
compared with baseline there was deterioration in mobility (PEDI functional skills scale, mobility<br />
domain) at 6 months that was not statistically significant, but there was a statistically significant<br />
improvement at 18 months. (VERY LOW) Another prospective case series reported an improvement<br />
in mobility (PEDI functional skills scale, mobility domain) at 12 months in children <strong>and</strong> young people<br />
who received CITB compared with baseline, although this was not statistically significant. (VERY<br />
LOW)<br />
One prospective case series reported that, compared with baseline, there was a statistically<br />
significant improvement in social functioning (PEDI functional skills scale, social function domain) at 6<br />
<strong>and</strong> 18 months in children <strong>and</strong> young people who received CITB. (VERY LOW) Another prospective<br />
case series reported an improvement in social functioning compared with baseline (PEDI functional<br />
skills scale, social function domain) at 12 months in children <strong>and</strong> young people who received CITB,<br />
although this was not statistically significant. (VERY LOW)<br />
With regard to optimisation of movement <strong>and</strong> function measured by PEDI caregiver assistance<br />
scores, one RCT found no statistically significant difference at 6 months in caregiver assistance<br />
between children <strong>and</strong> young people who received CITB <strong>and</strong> st<strong>and</strong>ard treatment, compared with those<br />
who received st<strong>and</strong>ard treatment only. (MODERATE) One prospective case series (a follow-up to the<br />
previous RCT) found no statistically significant difference in caregiver assistance at 12 months when<br />
compared with baseline. (VERY LOW) Another prospective case series found no statistically<br />
significant difference in the self-care <strong>and</strong> social function dimensions of caregiver assistance at 12<br />
months when compared with baseline. (VERY LOW) However, the same study provided evidence of<br />
a statistically significant improvement in the mobility dimension of caregiver assistance at 12 months<br />
when compared with baseline. (VERY LOW) One further prospective case series reported no<br />
statistically significant differences in the self-care dimension (at 6 <strong>and</strong> 18 months) <strong>and</strong> the mobility<br />
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