Peripheral B and T cell differentiation - University Institute of ...

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Leprosy: different clinical forms of the disease Lepromatous Leprosy: • Multiple, nodular lesions of the skin, in particular, of the face (”lion face"). • Persistent bacteriemia, foamy cell-like lesions with numerous M. leprae present Tuberculoid Leprosy: • Singular, small macular lesions of the skin. • Peripheral nerves (e.g. N. ulnaris, peronealis, N. auricularis) are often affected sensory neuropathy. • Granuloma are frequent (with only low numbers of M. leprae present)
Immunological Spectrum of Leprosy naïve CD4 T cells Th1 Th0 Th2 cellular immunity humoral immunity Tuberculoid leprosy Granuloma formation Tissue damage may ensue Lepromatous leprosy Persistence of M. leprae Disfiguring disorder
Page 1: Cellular and Molecular Immunology 3
Page 5 and 6: CD8 T cell differentiation
Page 7 and 8: Functional Heterogeneity of CD4 T L
Page 9 and 10: Naïve CD4 IL 4 IL 12 IFN Th 2 Th
Page 11: Leprosy • Chronic - progressive i
Page 15 and 16: Pathogens may influence the resulti
Page 17 and 18: # Publications per Year (PubMed) Pu
Page 20 and 21: IFN-mediated STAT1 signaling leads
Page 22 and 23: Mechanism(s) of suppression. Variou
Page 24: CD4 T-Zelle CD40L T-Zell-Hilfe durc

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