Peripheral B and T cell differentiation - University Institute of ...
Peripheral B and T cell differentiation - University Institute of ...
Peripheral B and T cell differentiation - University Institute of ...
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RAG-1, 2<br />
• RAG1 <strong>and</strong> RAG2 (“Recombination Activation Genes”)<br />
are essential for the rearrangement <strong>of</strong> the Ig <strong>and</strong> TCR<br />
genes<br />
• Mice deficient for either RAG1 <strong>and</strong>/or RAG2 are<br />
deficient for both T <strong>and</strong> B <strong>cell</strong>s (but may still have some<br />
NK <strong>cell</strong>s)<br />
• to prevent the later generation <strong>of</strong> autoreactive T <strong>and</strong> B<br />
<strong>cell</strong>s, the expression <strong>of</strong> these two genes needs to be<br />
tightly regulated
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