Peripheral B and T cell differentiation - University Institute of ...

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Figure 1 Stimulating the Th1 or Th2 response. In both pathways, dendritic cells internalize the pathogen. They present its antigens to T cells, which recognize antigens through their T-cell receptors (TCR). a, Organisms such as intracellular bacteria or viruses are recognized by the Toll-like receptors on dendritic cells; the resulting signals induce the secretion of interleukin-12 (IL-12) and differentiation of CD4 T cells into the Th1 lineage that produces gamma interferon (IFN-). b, How dendritic cells recognize larger pathogens, such as parasitic worms, is not known. But the end result is differentiation of Th2 effector cells regulated by T-cell-produced interleukin-4 (IL-4). Information1, 2 on the link between dendritic cells and T cells suggests that the former express different Notch ligands — Delta or Jagged — under different conditions. Jagged is specifically induced by stimuli known to induce Th2 differentiation. Notch signals (Notch-IC) can induce transcription of IL-4 through direct binding of RBPJ to the IL-4 promoter1 Nature 430, 150 - 151 (08 July 2004)
# Publications per Year (PubMed) Publications on Suppressor T cells and Regulatory T cells 300 250 200 Suppressor T cells Regulatory T cells 150 100 50 0
Page 1: Cellular and Molecular Immunology 3
Page 5 and 6: CD8 T cell differentiation
Page 7 and 8: Functional Heterogeneity of CD4 T L
Page 9 and 10: Naïve CD4 IL 4 IL 12 IFN Th 2 Th
Page 11 and 12: Leprosy • Chronic - progressive i
Page 13 and 14: Immunological Spectrum of Leprosy n
Page 15: Pathogens may influence the resulti
Page 20 and 21: IFN-mediated STAT1 signaling leads
Page 22 and 23: Mechanism(s) of suppression. Variou
Page 24: CD4 T-Zelle CD40L T-Zell-Hilfe durc

Peripheral B and T cell differentiation - University Institute of ...

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