Peripheral B and T cell differentiation - University Institute of ...

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Mechanism(s) of suppression. Various molecular and cellular events have been described to explain how Treg can suppress immune responses. They include: IL-2 gene expression inhibition, modulation of costimulatory molecules on APCs and interaction of LAG3 with MHC class II molecules (a), immunosuppressive cytokine secretion (b), induction of tryptophan catabolism through CTLA-4 (c) and cytotoxicity (d). However, none of those mechanisms can explain all aspects of suppression. It is probable that various combinations of several mechanisms are operating, depending on the milieu and the type of immune responses. It is also possible that there might be a single key mechanism that has not been found yet (e). Abbreviations: APC, antigen presenting cell; TCR, T cell receptor.
B cells ….
Page 1: Cellular and Molecular Immunology 3
Page 5 and 6: CD8 T cell differentiation
Page 7 and 8: Functional Heterogeneity of CD4 T L
Page 9 and 10: Naïve CD4 IL 4 IL 12 IFN Th 2 Th
Page 11 and 12: Leprosy • Chronic - progressive i
Page 13 and 14: Immunological Spectrum of Leprosy n
Page 15 and 16: Pathogens may influence the resulti
Page 17 and 18: # Publications per Year (PubMed) Pu
Page 20 and 21: IFN-mediated STAT1 signaling leads
Page 24: CD4 T-Zelle CD40L T-Zell-Hilfe durc

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