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download pdf - Department of Pediatrics - University of Miami

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Sickle Cell Research: Ongoing Studies<br />

• Stroke With Transfusions Changing to<br />

Hydroxyurea (SWiTCH)<br />

<br />

<br />

<br />

Multi-center, randomized cross-over clinical trial<br />

130 children 6-18 years with infarct treated with<br />

transfusion for at least 18 months<br />

Outcomes<br />

• Secondary stroke<br />

• Management <strong>of</strong> iron overload<br />

• Neurodevelopment<br />

• Quality <strong>of</strong> life

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