download pdf - Department of Pediatrics - University of Miami
download pdf - Department of Pediatrics - University of Miami
download pdf - Department of Pediatrics - University of Miami
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
Sickle Cell Disease: Background<br />
• Hemoglobinopathy<br />
(HbS) affecting 1 in 800<br />
Black babies born in the<br />
United States<br />
• Newborn screening<br />
detects approximately<br />
2000 new cases each<br />
year<br />
• Most common variants<br />
are HbSS, HbSβ-thal,<br />
HbSβ0, and HbSC<br />
• Carriers (HbS-trait-FAS,<br />
FAC, FAE) are<br />
assumed asymptomatic;<br />
ratio <strong>of</strong> trait to SCD is<br />
50:1<br />
2