Treatment of Nicotine Addiction in Primary Care
Treatment of Nicotine Addiction in Primary Care
Treatment of Nicotine Addiction in Primary Care
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Bupropion<br />
• Beg<strong>in</strong> bupropion a week before the quit date<br />
• Normal dose 150mg bd, (reduce <strong>in</strong> elderly, liver/renal disease)<br />
• Contra-<strong>in</strong>dicated <strong>in</strong> patients with epilepsy, anorexia<br />
nervosa, bulimia, bipolar disorder or severe liver disease.<br />
• The most common side effects are <strong>in</strong>somnia (up to 30%),<br />
dry mouth (10-15%), headache (10%), nausea (10%),<br />
constipation (10%), and agitation (5-10%)<br />
• Interaction with antidepressants, antipsychotics and antiarrhythmics<br />
Bupropion <strong>in</strong>creases the odds <strong>of</strong> quitt<strong>in</strong>g about 2 fold<br />
Hughes J, et al. Antidepressants for smok<strong>in</strong>g cessation. Cochrane Database Systematic Reviews 2007
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