Treatment of Nicotine Addiction in Primary Care

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Cahill K, et al. Nicotine receptor partial agonists for smoking cessation. Cochrane Database Syst Rev 2007 Varenicline • Begin varenicline a week before the quit date, increasing dose gradually. • Alleviates withdrawal symptoms, reduces urge to smoke • Common side effects include: nausea (30%), insomnia, (14%), abnormal dreams (13%), headache (13%), constipation (9%), gas (6%) and vomiting (5%). • Contra-indicated in pregnancy • New drug Varenicline increases the odds of quitting about 2.5 fold
SIDE EFFECTS • Neuropsychiatric side effects with varenicline were first publicly reported by the Food and Drug Administration (FDA) on November 20, 2007. • In a public health advisory issued on February 1, 2008, the agency stated, “As FDA's review of the data has progressed it has become increasingly likely that the severe changes in mood and behavior may be related to Chantix.” Food and Drug Administration. Public health advisory: important information on Chantix (varenicline). (Accessed January 23, 2009, at http://www.fda.gov/cder/drug/advisory/varenicline.htm.)
Page 1 and 2: Treatment of Nicotine Addiction in
Page 3 and 4: Objectives • Definitions • Epid
Page 5 and 6: Definitions • Addiction is a prim
Page 7 and 8: Is Nicotine Addictive? • Of prima
Page 9 and 10: Is Nicotine Addictive? • Cigarett
Page 11 and 12: Is Nicotine Addictive? • Nicotine
Page 13: Aspects of Nicotine Addiction Socia
Page 16 and 17: How Prevalent Is The Problem? •To
Page 18 and 19: Adolescent Smoking Nearly all smok
Page 20 and 21: Mental health • Psychotic disorde
Page 23 and 24: The cycle of change Ambivalent to c
Page 25 and 26: The cycle of change Action! a cessa
Page 27 and 28: Self-Help Materials • Appear to i
Page 29 and 30: Individual Counseling • Improves
Page 32 and 33: Pharmacotherapy Pharmacotherapy + b
Page 34 and 35: NRT: Nicotine patches 20 15 10 Ciga
Page 36 and 37: NRT: Nicotine gum 20 Cigarette (1-2
Page 38 and 39: Bupropion • Begin bupropion a wee
Page 42 and 43: Side Effects • On June 16, 2011,
Page 44 and 45: HIV Disease: Changing Paradigm •
Page 46 and 47: Acute Myocardial Infarction NY: Dis
Page 48 and 49: “Cessation of smoking is more lik
Page 50 and 51: Impact of Cigarette Smoking on Mort
Page 52: Cigarette Smoking and Quality Of Li
Page 55 and 56: Smoking And Mental Health
Page 57 and 58: Smoking and Schizophrenia •High p
Page 59 and 60: Smoking & Bipolar Disorder •High
Page 61 and 62: Smoking and Depression (Continued)
Page 63 and 64: SSRIs and Smokers with Anxiety Diso
Page 65 and 66: Smoking and Alcohol Dependence (Con
Page 67 and 68: Organization U.S. Dept. of Health &
Page 70 and 71: Conclusions •Tobacco use is a maj

Treatment of Nicotine Addiction in Primary Care

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