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Treatment of Nicotine Addiction in Primary Care

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Side Effects<br />

• On June 16, 2011, the FDA issued a safety<br />

announcement that Chantix may be associated<br />

with a "a small, <strong>in</strong>creased risk <strong>of</strong> certa<strong>in</strong><br />

cardiovascular adverse events <strong>in</strong> patients who<br />

have cardiovascular disease.”<br />

• On July 4, 2011, four scientists published a<br />

review <strong>of</strong> double-bl<strong>in</strong>d studies stat<strong>in</strong>g that the<br />

use varencil<strong>in</strong>e carries an <strong>in</strong>creased risk <strong>of</strong><br />

serious adverse cardiovascular events<br />

compared with placebo.<br />

"FDA Drug Safety Communication: Chantix (varenicl<strong>in</strong>e) may <strong>in</strong>crease the risk <strong>of</strong> certa<strong>in</strong> cardiovascular adverse<br />

events <strong>in</strong> patients with cardiovascular disease". 06/16/2011<br />

Risk <strong>of</strong> serious adverse cardiovascular events associated<br />

with varenicl<strong>in</strong>e: a systematic review and meta-analysis. CMAJ 2011. DOI:10.1503 /cmaj.110218

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