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Reaction of Furan and Thiophene

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3) Halogenation<br />

NBS<br />

S<br />

S<br />

Br<br />

X<br />

X<br />

O<br />

X 2 / r.t<br />

x= Clor Br<br />

X<br />

O<br />

X<br />

Cl 2 / CH 2 Cl 2<br />

- 40 C°<br />

Br 2 / Dioxane<br />

O<br />

Cl<br />

0 C ° O Br<br />

Indirect insertion <strong>of</strong> iodine in furan ring<br />

I 2 / KI<br />

O<br />

COOH<br />

KOH<br />

O I<br />

Heterocyclic Chemistry

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