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Reaction of Furan and Thiophene

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4) Lithiation<br />

X<br />

X = O, S<br />

BuLi<br />

X<br />

Li<br />

RX<br />

X<br />

R<br />

5) Diazocoupling:<br />

<strong>Furan</strong> <strong>and</strong> thiophene can not couple with diazonium salts<br />

which shows that they are less reactive than pyrrole.<br />

O<br />

Ar N=N + Cl -<br />

No <strong>Reaction</strong><br />

S<br />

Heterocyclic Chemistry

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