Reaction of Furan and Thiophene
Reaction of Furan and Thiophene
Reaction of Furan and Thiophene
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) Monosubstituted furan & thiophene with electron donating group such as CH 3 , OH, NH 2 ,<br />
OCH 3<br />
i) EDG at position 2<br />
E + O COCH 3<br />
X<br />
EDG<br />
More reactive than unsubstituted<br />
compound<br />
E<br />
X<br />
EDG<br />
(incoming E + is directed to position 5)<br />
ii) EDG at position 3<br />
EDG<br />
X<br />
EDG<br />
EDG<br />
or<br />
E + X E<br />
E X<br />
(incoming E + directed to 2 mainly or 5 due to steric effects )<br />
CH 3 CH 3<br />
Ac 2 O / r.t.<br />
+<br />
CH 3<br />
O<br />
25 % H 3 PO 4<br />
H 3 COC<br />
O<br />
Heterocyclic Chemistry
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