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T. reesei - TNAU Genomics

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Proteomics to identify what membrane<br />

proteins socialise in cancer metastasis<br />

(identify binding partners of uPAR)<br />

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1. Dysregulation of proteolytic machinery<br />

at invasive edge of tumours (uPAR)<br />

2. Changes in cell adhesive properties as<br />

cancer becomes malignant (integrins)<br />

3. Differential responses to existent<br />

growth signalling pathways changes in<br />

malignancy (TGFb etc)<br />

uPAR<br />

37<br />

Saldanha et al., J Proteome Res. 2007 6: 1016-1028.

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