T. reesei - TNAU Genomics
T. reesei - TNAU Genomics
T. reesei - TNAU Genomics
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Proteomics to identify what membrane<br />
proteins socialise in cancer metastasis<br />
(identify binding partners of uPAR)<br />
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1. Dysregulation of proteolytic machinery<br />
at invasive edge of tumours (uPAR)<br />
2. Changes in cell adhesive properties as<br />
cancer becomes malignant (integrins)<br />
3. Differential responses to existent<br />
growth signalling pathways changes in<br />
malignancy (TGFb etc)<br />
uPAR<br />
37<br />
Saldanha et al., J Proteome Res. 2007 6: 1016-1028.