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Examples of ethnicity and geography issues in global clinical trials ...

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Primary Outcome Sub-groups (3)<br />

Dabigatran110 vs. WARFARIN<br />

Dabigatran150 vs. WARFARIN<br />

P(INTER)<br />

P(INTER)<br />

NORTH AMERICA<br />

SOUTH AMERICA<br />

WESTERN EUROPE<br />

CENTRAL EUROPE<br />

SOUTH ASIA<br />

EASTERN ASIA<br />

OTHER REGION<br />

0.91<br />

0.11<br />

ASA<br />

NO ASA<br />

0.69<br />

0.95<br />

AMIODARONE<br />

NO AMIODARONE<br />

0.07<br />

0.14<br />

PPI<br />

NO PPI<br />

0.34<br />

0.16<br />

0.50 1.00 1.50<br />

0.50 1.00 1.50<br />

Dabigatran better<br />

Warfar<strong>in</strong> better<br />

Dabigatran better<br />

Warfar<strong>in</strong> better

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