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Examples of ethnicity and geography issues in global clinical trials ...

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Cumulative <strong>in</strong>cidence (%)<br />

PLATO: primary endpo<strong>in</strong>t:<br />

K-M estimate <strong>of</strong> time to major CV event<br />

(composite <strong>of</strong> CV death, MI or stroke)<br />

13<br />

12<br />

11<br />

10<br />

9<br />

8<br />

7<br />

6<br />

5<br />

4<br />

3<br />

2<br />

1<br />

0<br />

Clopidogrel<br />

Ticagrelor<br />

(HR, 0.84; 95% CI, 0.77-0.92; P

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