Examples of ethnicity and geography issues in global clinical trials ...
Examples of ethnicity and geography issues in global clinical trials ...
Examples of ethnicity and geography issues in global clinical trials ...
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Ethnicity <strong>and</strong> <strong>geography</strong> <strong>issues</strong><br />
<strong>in</strong> <strong>global</strong> cl<strong>in</strong>ical <strong>trials</strong> <strong>of</strong> ACS <strong>and</strong> AF<br />
• Play <strong>of</strong> chance – correction for multiplicity, small patient<br />
numbers <strong>in</strong> geographical subgroups<br />
• Problems with study performance <strong>and</strong> procedures <strong>in</strong><br />
specific geographical area<br />
• Differences <strong>in</strong> compliance<br />
• Differences <strong>in</strong> patient characteristics, co-morbidities,<br />
medical treatments might modulate the treatment effect<br />
• Differences <strong>in</strong> pharmacogenetics, response genetics<br />
• Seldom biological rationale for geographical differences
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