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Ladda ner den kompletta programboken här! - SFAI-veckan 2013

Ladda ner den kompletta programboken här! - SFAI-veckan 2013

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NEW METHODS FOR NEUROPATHIC PAIN TREATMENT<br />

SAL 2 16.00-17.30<br />

EVIDENCE-BASED TREATMENT OF NEUROPATHIC PAIN<br />

Per Hansson, Professor/senior consultant/section head, Section of neuropathic pain, Pain center,<br />

Dept. of Anesthesiology and Intensive Care, Karolinska University Hospital, Solna,<br />

Several guidelines for pharmacological treatment of neuropathic pain have been published in recent years. The<br />

lecture will highlight the recommendations published in 2010 by the European Federation of Neurological<br />

Societies (EFNS). In addition, the EFNS guidelines on neurostimulation will be briefly reviewed.<br />

NON-INVASIVE BRAIN STIMULATION: A NEW TREATMENT OPTION FOR PAIN<br />

Didier Bouhassira, MD, PhD, INSERM U987, « Pathophysiology and Clinical Pharmacology of Pain »<br />

Ambroise Pare Hospital, 92100 Boulogne-Billancourt, France<br />

Repetitive Transcranial Magnetic Stimulation (rTMS) and transcranial Direct Current Stimulation (tDCS) are<br />

non invasive brain stimulation (NIBS) techniques which have raised an increasing interest in recent years for the<br />

treatment of various pain conditions, including not only peripheral and central neuropathic pain syndromes, but<br />

also non neuropathic pain syndromes such as fibromyalgia.<br />

A large number of randomized sham-controlled trials have confirmed that it is possible to induce analgesic<br />

effects lasting up to several days after a single session of stimulation of the primary motor cortex or dorsolateral<br />

prefrontal cortex. More recently, it has been shown that it is possible to maintain the analgesic effects of rTMS<br />

of the primary motor cortex in patients with chronic pain over more than 6 months, strengthening the idea that<br />

NIBS could represent a valid option for the treatment of chronic pain patients.<br />

Although the mechanisms of the analgesic action of NIBS are still poorly understood, recent studies have<br />

suggested that they depend on endogenous opioid system and changes in cortical excitability.<br />

CAPSAICIN FOR PERIPHERAL NEUROPATHIC PAIN<br />

Per Hansson, Professor/senior consultant/section head, Section of neuropathic pain, Pain center,<br />

Dept. of Anesthesiology and Intensive Care, Karolinska University Hospital, Solna<br />

Qutenza is a dermal patch of high-concentration capsaicin (8%) developed to rapidly deliver a therapeutic<br />

dose of capsaicin into the skin. Qutenza is indicated for the treatment of peripheral neuropathic pain in nondiabetic<br />

adults. Approval of the drug by the European Medicinal Agency was based on clinical trials conducted<br />

in adult patients with post herpetic neuralgia or HIV- associated painful polyneuropathy. The lecture will probe<br />

mechanisms of action of capsaicin, review recently published studies on Qutenza and results from a recent<br />

Swedish multicenter observational study.<br />

PROGRAM<br />

26

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