An Absolute Review on Oxalis corniculata Linn. - International ...

International Journal of Research in Pharmaceutical and Biomedical Sciences ISSN: 2229-3701
100% lysis at 100 microg/ml and cytotoxicity below
the trypanocidal concentration. The new alkyl phenol
3-heptadecyl-5-methoxy-phenol was active towards
Leishmania amazonensis and Leishmania donovani
promastigotes with 100% lysis at100 microg/ml. The
cytotoxicity of embelin and the new alkyl phenol 7 .
High-performance liquid chromatography (HPLC)-
diode array detection (DAD)-mass spectrometry
(MS) techniques have been successfully employed in
the identification of the anthocyanins of the coloured
tubers of isla oca (Oxalis tuberosa), the second most
cultivated tuber in the <strong>An</strong>dean region. Tubers
underwent a pre-treatment step in order to inhibit
enzymatic reactions and to obtain a stable powder or
"concentrate". This concentrate was dissolved,
purified and then analysed. Eight different
compounds were found. The major peaks were
malvidin glucosides (malvidin 3-O-glucoside and 3,
5-O-diglucoside). The rest of the peaks were 3,5-Odiglucosides
of petunidin and peonidin, and 3-Oglucosidesof
delphinidin, petunidin and peonidin.
Only malvidin 3-O-acetylglucoside-5-O-glucoside
was found as an acylated anthocyanin 8 .
Seven new cinnamic ester derivatives (1- 7) were
isolated from a methanol extract of the fresh leaves
and twigs of Oxalis pes-caprae (Bermuda buttercup).
The effects of compounds 1- 7 on the germination
and growth of Lactuca sativa (lettuce) were studied 9 .
Three C-glycosylflavones in the leaves of Oxalis
corniculata, the host plant of the lycaenid butterfly
pale grass blue (Pseudozizeeria maha), were
identified as 6-C-glucosylluteolin (isoorientin), 6-Cglucosylapigenin
(isovitexin) and isovitexin 7-methyl
ether (swertisin) 10 . The fresh leaves and twigs of the
plant were crumbled and extracted with AcOEt. The
solution was concentrated, and separated into acidic
and neutral fractions. The crude neutral residue was
fractionated by chromatographic procedures,
followed by structure elucidation on the basis of 1Hand
13C-NMR, and MS data analysis, and six new
phenyl cinnamate derivatives were identified. The
phytotoxic effects of the isolated compounds on the
germination and growth of the dicotyledon Lactuca
sativa L. (lettuce) were studied in the concentration
range from 10(-4) to 10(-7) M. Lactuca sativa
(lettuce) were studied 11 . The fresh leaves and twigs
of Oxalis pes-caprae were crumbled and extracted
with ethyl acetate and methanol. The extracts were
fractionated by Chromatographic procedure ,
followed by structure elucidation using mass
spectrophotometry and (1) h- and (13) c- NMR
spectroscopy and a new phenyl cinnamate
derivatives was identified , along with some known
compound 12 .
Ten fatty acid alkyl esters isolated from Oxalis
triangularis, were evaluated for the effects on
melanogenesis using mouse B16 melanoma cells.
Treatment of methyl linoleate, methyl
linolenate,ethyl linoleate and ethyl linolenate
significantly blocked forskolin-induced
melanogenesis and inhibited tyrosinase activity. In
addition, we found that they inhibited cAMP
production, suggesting that their anti-melanogenic
effect is mediated by the inhibition of cAMP
production. We concluded that methyl/ethyl linoleate
and linolenate isolated from Oxalis triangularis have
pigment inhibition activity. These compounds may be
useful as the cosmetic agent to stimulate skin
whitening 13 .
The present study evaluated the protective potential
of aqueous extract of Oxalis corniculata (OCE)
against isoproterenol (ISO) induced myocardial
infarction in rats. Myocardial infarction in rats was
induced by isoproterenol (200 mg/kg) at an interval
of 24 h for 2 days. OCE was given to rats as
pretreatment for 30 days orally using an intragastric
tube. Isoproterenol caused a significant increase in
the activity of cardiac injury marker enzymes like
creatine phosphokinase (CPK) and lactate
dehydrogenase (LDH) and increased the
concentration of serum lipids. OCE pretreatment
significantly reduced the concentration of CPK,
LDH, serum total cholesterol, LDL cholesterol and
triglycerides. OCE also reduced the activity of
lipogenic enzyme; glucose-6-phosphate
dehydrogenase in ISO administered rats. Oxidative
stress produced by isoproterenol was significantly
lowered by the administration of OCE which was
evident from increased activities of antioxidant
enzymes (catalase and superoxide dismutase) and
reduced concentration of lipid peroxidation products
(TBARS and conjugated dienes). Concentration of
vitamin C, protein sulfhydryl groups and reduced
glutathione (GSH) was also high in OCE pretreated
rats. Histopathology of heart of ISO administered rat
pretreated with OCE showed normal myocardium
with very little evidence of inflammatory infiltration.
Results of our in vitro findings also confirmed that
OCE exhibits significant antioxidant and radical
scavenging activity against DPPH, superoxide and
nitric oxide radicals. These findings provided
evidence that Oxalis Corniculata was found to be
protecting the myocardium against ischemic insult
and the protective effect could attribute to its
antioxidative and antihyperlipidemic activities 14 .
GENETICS
Frequencies of floral morphs in progenies obtained
from a complete set of diallelic crosses among three
accessions of tristylous, octoploid oca (Oxalis
tuberosa) were used for a Mendelian analysis of
floral morph inheritance. The frequencies observed
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