THE ALEXANDER FLEMING PAPERS - British Library

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i) Adamson: pyorrhoea, gastritis and gastric ulcer (17 March 1921) ii) Courtney: rheumatoid arthritis iii) Hollis: rheumatoid arthritis iv) Wiseman: rheumatoid arthritis v) Oswold: ‘Out of sorts’; 11 April 1921. vi) Power: pyorrhoea and rheumatism; 10 Nov. 1921. vii) Barker: old appendix (Removed) and diarrhoea; 11 Nov. 1921. viii) Nieltsen: O. P, rheumatoid arthritis; 10 Nov. 1921. ix) Bokenam: no description of complaint x) Baby Weasley: asthma, bowel disturbances; 10 Nov. 1921. xi) Howe: rheumatoid xii) Unknown sample, possible second sample from Howe; 11 Nov. 1921. xiii) Garrett: rheumatoid xiv) Bennett: rheumatoid xv) Singey: unknown complaint xvi) Cook: pyorrhoea, senility xvii) Holloway: rheumatoid arthritis; 11 Nov. 1921. xviii) Thomas – rheumatoid arthritis xix) Jynam – sciatica xx) Patrick – colitis and rheumatoid pains xxi) Gordon – rheumatism; 3 May 1921. xxii) R. S. F: ‘Feels seedy’; 4 May 1921. xxiii) Wise: O. P, rheumatoid; 6 May 1921. xxiv) Kitchener: O. P, rheumatoid xxv) Nielsen: O. P, rheumatoid xxvi) Hollis: O. P, rheumatoid Section three: 1. f. 47. List of haemolytic coli; n.d. Section four: 31 March-8 June 1921. ff. 78-95. Tuberculosis and Tubercle Fixation i) Complement fixation of TB ii) Tubercle fixation iii) Tubercles fixations – heated versus fresh serum iv) Fixation with different types of antigen v) TB fixation – comparison of Douglas antigen and living TB vi) TB fixation incubator versus ice chest vii) Fixation in an incubator viii) Duggies antigen - fresh tube of old broth ix) Duggies versus live TB x) Comparison of antigens Section five: 12-19 April 1921. ff. 113-115. Experiments examining the phagocytic bactericidal power to streptococcus and staphylococcus.
Section six: 1. f. 127. Table showing the serological reaction of types of faecal streptococci in the presence of antiserum of the [ ] type (altson 7) Section seven: 21 Nov. 1921-5 Jan. 1922. ff. 135-146, 152. Discovery of lysozyme Initial discovery made on 21 Nov. 1921 and is noted as ‘bacteriophage’ with a diagram of the agar plate. The reaction was caused by nasal mucus but Fleming extended his experiments to include tears and saliva and other substances. As a result of this finding Fleming carried out a range of experiments. i) Experiments with B. coli, pneumo, AF coccus, staphylococcus and streptococcus on blood agar plates ii) Broth tubes planted thickly with AF coccus iii) Resistance to heat of lytic substance iv) Effect of dilution on the lytic substance v) Effect of proteid precipitants on lytic agent vi) Acids and alkalines on lytic substance vii) Various experiments with samples taken from the body – hair, skin, nails, pus, ear wax, sweat and urine viii) Experiments with guinea pig organs ix) Experiments to test for the substance in vegetables – turnip, parsnip, artichoke, cabbage, potato and carrot x) Experiments to test for the substance in rabbit organs xi) Experiments to test for the substance in human tissues xii) Experiments with Allison’s tears xiii) Experiments with dilution of tears, saliva and blood xiv) Pieces of interior of a tonsil and mucus membrane added to ice suspension of nasal mucus Section eight: ff. 163-178, 180, 188v. Microzyme On the discovery of the same reaction with tears Fleming named the tear related substance ‘microzyme’. The term ‘lysozyme’ was not used until later, see notebook 56155. i) Quantity in cartilage ii) Rate of lysis at temperature iii) Effect of heat on microzyme in saliva iv) Effect of heat on microzyme in sputum v) Rate of lysis at temp. of tears vi) Effect of boiling on microzyme in tears vii) Blood content of microzyme viii) On strepto faecalis ix) Action in tears on various strains of human streptococci.
Page 1 and 2: THE ALEXANDER FLEMING PAPERS Additi
Page 3 and 4: INTRODUCTION When Sir Alexander Fle
Page 5 and 6: FLEMING PAPERS 56106-56225. Corresp
Page 7 and 8: 56107. FLEMING PAPERS. Vol. II (ff.
Page 9 and 10: Including: Food and Drug Administra
Page 11 and 12: Switzerland, April 1953 56121. Vol.
Page 13 and 14: All Pakistan Medical Conference Rec
Page 15 and 16: C. NOTEBOOKS 56138-56183. FLEMING P
Page 17 and 18: ff. ii + 67. 245 x 204mm. Hard, gre
Page 19 and 20: uncomplicated scarlet fever of a ma
Page 21 and 22: 11. ff. 50-54. Experiments relating
Page 23 and 24: 1. ff. 1, 4v-8. Series of experimen
Page 25 and 26: 4. f. 4. Rossiter: Three wounds in
Page 27 and 28: its outcome. In some cases there ar
Page 29: 56150 and 56151: Work with patients
Page 33 and 34: Section four: 1. f. 72. Intracellul
Page 35 and 36: ii) Chlorides on bactericidal power
Page 37 and 38: Section twelve: 3 March 1927-28 Nov
Page 39 and 40: xi) Opsonics centrifuged and incuba
Page 41 and 42: f. 50. Notes from Medical Research
Page 43 and 44: i) On Allen I slide cells ii) On st
Page 45 and 46: and acid fuschin xii) Development o
Page 47 and 48: pneumo a. Comparison between killin
Page 49 and 50: iv) Disappearance of inhibitory sub
Page 51 and 52: 4. f. 20. Notes on ‘Milly’ baci
Page 53 and 54: 36. f. 83. Experiments with three m
Page 55 and 56: ii) Church: postnasal arthritis iii
Page 57 and 58: i) Leesmith: old chronic arthritis
Page 59 and 60: ii) Diagram of an agar plate with h
Page 61 and 62: Notebook includes: Section one: 1.
Page 63 and 64: 56169. Vol. LXIV. 1 Jan.-28 Nov. 19
Page 65 and 66: 2. f. 160. Experiment using a penic
Page 67 and 68: Gratia, CR Soc Biol, 1923, 89, 826
Page 69 and 70: 1. f. 79. Eusol, iodine and phenol
Page 71 and 72: 3. f. 205v. Shiga agglutination usi
Page 73 and 74: xiv) Absorption by streptococcus Se
Page 75 and 76: v) Comparison of living and boiled
Page 77 and 78: 1. ff. 279-291. Hodges and Mills se
Page 79 and 80: i) On staphylococcus ii) Staphyloco
Page 81 and 82:
9. f. 152v. Sterilisation of rough
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v) Paccito: resistant gonorrhoea vi
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5. ff. 197-201v. Staphylococcus ver
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7. f. 367. Proteus sensitivity to p
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2. ff. 29v-30v, 31v-34. Titration o
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8. f. 57v. Drexler - blood penicill
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ii) The rhythmic alteration of [sal
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ff. 20-21. Notes on agglutination f
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i) Lancet leader 1930, 2, 974 ii) K
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v) Graph to show the affect of inje
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1. f. 87. Drawings of normal B. typ
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4. f. 198. Notes of treatment for A
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8. f. 299. Letter from G. Roche Lyn
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Afternoon Guard of Honour of Black
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Section four: 14-22 Sept. [1945]. f
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Section three: 6-10 Dec.1945. ff.16
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29 March. Council Members meeting.
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28 Aug. St Andrews and back to Dund
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29 May. Flight home. Section two. n
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29 June. Interviews for television
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Section four: n.d. ff. 32v-34. Name
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Met Sir Gerald Campbell, previous C
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26 Aug, Flight to London. Section t
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3. f. 6v. Interview with Daily Mail
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7 Oct. Visit to Milanides Institute
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ff. 1-4. Rome: International Congre
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28 March. Salt Lake City to Las Veg
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E. MISCELLANEOUS 56206-56213. FLEMI
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F. BIOGRAPHICAL MATERIAL 56214. FLE
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G. NOTEBOOKS OF COLLEAGUES 56223-56
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31. ff. 101-103. Two hundred observ
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iii) On blood 23. ff. 56-57v. Extra
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14. f. 61. Selected staph grown in
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Aitken (William Maxwell), 1st Baron
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— Photograph of A. Fleming receiv
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— Experiments by A. Fleming rel.
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Beattie (James Martin), pathologist
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Blait-Low (F. S.), Honorary Scienti
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British Council. Programme for A. F
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Cadogan (Hon. Sir Edward Cecil Geor
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Central Chancery of the Orders of K
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Clausse (Roger), Director of Interv
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Council for the Coordination of Int
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Davis (J. G), physician; Joint Hono
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Dyson (C. B.), of the Inoculation D
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[Eveling?] (J. W.), of the British
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— Draft letter congratulating the
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— Summary of Harben Lectures, Nov
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— A. Fleming's journal entries fo
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Fourth International Congress of Ot
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— List of published scientific pa
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Page 185 and 186:
Hendricks (C. M.), Executive Direct
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Horton-Smith-Hartley (Sir Percival)
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to Human Leucocytes' published in t
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Jones (Ranald Montagu Handfield-).
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King (Harold), chemist. Corre- spon
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Leblanc (F.), Administrator, Uni- v
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— ROYAL COLLEGE OF SURGEONS. Summ
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McDonnell (John J.), Director, Offi
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Magnus (Henry Adolph), M.D.; anatom
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Mayhan ([E. G?]), Director, The Dis
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—Two lectures by A. Fleming, made
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— Note from the Chairman on new B
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—Italy. 'Epoca'. Article about A.
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Streptomycin Dependent Mutant of Br
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Page 215 and 216:
Page 217 and 218:
Pimlott (J. A. R.), of the Home Off
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Reynolds (Betty), researcher, Wrigh
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Ross (Sandy), of Nairobi. Letter co
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— Photograph of a micromanipulato
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— Report on the Congress, 6-12 Se
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Stedman (W. J.), Chairman, Public B
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Taylor (G. McKean). v. McKean Taylo
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— Two lectures by A. Fleming enti
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Wedderburn (Sir Ernest) Rector's As
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Wood (George A.), Cadet Officer, Br
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