THE ALEXANDER FLEMING PAPERS - British Library

Section nine:
1. f. 185. Temperature on the velocity of lysis
2. ff. 186-187. Experiments to test for the substance in dogs’ tissues; 28
Jan. 1921.
3. f. 188. Bactericidal experiment with tears and B. abortus (Bang’s
bacillus) includes a diagram.
56155. Vol. L. 16 Feb. 1922-10 June 1923.
ff. ii + 237. 324 x 204mm. Hard red cover. Inside the front cover is a label
for ‘W. Isacke, Account Book Maker, 211 Edgeware Road, London’.
Fleming used sections of the book at different times and/or
simultaneously, and he also has gone back and re-used sections of the
notebook at later dates.
Notebook includes:
f. 5. Unfinished contents list.
Section one: 16 Feb.-April 1922.
ff. 6-35, 39-40, 51, 55. Absorption and action of ‘microzyme’ on cocci
i) Microzymes on cocci
ii) Calculation of absorption
iii) Absorption of tear microzyme with AF cocci
iv) Tears and egg on streptococci
v) Absorption of microzyme
vi) The lytic power of emotional tears
vii) Streptococci on eggs and tears
viii) Serum lysozyme after inoculation (first use of the word
lysozyme in these notebooks f. 34)
ix) Pus lysozyme and different treatments
x) Absorption of ‘lysozyme’ in tears (f. 38)
Section two: n.d.
ff. 36-38, 56. Resistance
i) Resistant strains of AF coccus
ii) Resistance of nasal mucus resistant strain AF coccus to other
extracts and secretions
iii) Resistant forms of AF coccus second generation (f. 39)
Section three; n.d.
ff. 41-50, 52-53. Bactericidal
i) Experiments examining the effect of lysozyme in tears and
albumen on various substances and bacteria– sanjarian, B. coli,
Pullonin, Chick. B, Canary Cholera, Avisetieus,
staphylococcus, Abortus Bang, B. pestis, P. T. B, Rodets
ii) Experiment involving an extract of brain and Fleming’s extract
versus coli, typhoid etc.
iii) Experiment comparing mouth and throat streptococcus with
tears, nasal mucus and extract from the tonsils