Non-HDL-C
Non-HDL-C
Non-HDL-C
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Log-linear Relationship Between LDL-C Levels and<br />
Relative Risk for CHD<br />
3.7<br />
Relative<br />
Risk<br />
for<br />
Coronary<br />
Heart<br />
Disease<br />
(Log Scale)<br />
2.9<br />
2.2<br />
1.7<br />
1.3<br />
1.0<br />
40 70 100 130 160 190<br />
LDL-Cholesterol, mg/dL<br />
• This relationship is consistent with a large body of epidemiological data and with data<br />
available from<br />
clinical trials of LDL-lowering therapy<br />
• These data suggest that for every 30-mg/dL change in LDL-C, the relative risk for CHD is<br />
changed in proportion by about 30%. The relative risk is set at 1.0 for LDL-C 40 mg/dL.<br />
Grundy S, et al. Circulation. 2004;110:227-239
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