Autonomic Nervous System

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BIMM118 Cholinergic <strong>System</strong> - Antagonists Muscarinic Parasympatholytics Clinical applications: • Atropine: – before anesthesia: prevent hypersecretion of bronchial mucus – Bradycardy – Acetylcholinesterase-inhibitor and mushroom poisoning – Ophtalmology (eye exams) • Scopolamine: – Motion sickness (as patches) • Ipratropium: – Inhalation for asthma and bronchitis • Pirenzepine: – Peptic ulcers: selectively inhibits M1 receptors (gastric mucosa) => reduced gastric acid production • N-Butyl-scopolamine: – Spasmolytic (intestinal or menstrual cramps)
BIMM118 Cholinergic <strong>System</strong> - Antagonists Nicotinic Parasympatholytics Two classes (both act as neuromuscular blockers => muscle relaxants): • Competitive antagonists = Nondepolarizing blockers – Act by competing with AcCh for binding to the N receptors – Prevent depolarization of the endplate – Action can be reversed by increasing AcCh concentrations (e.g. via AcCh-esterase inhibitors) • Agonists = Depolarizing blockers – AcCh mimetics that are not hydrolyzed by AcCh-esterase (but hydrolyzed by plasma esterases) – Act by triggering a sustained depolarization of the neuromuscular endplate – No new action potential can be generated – Can NOT be reversed increasing AcCh concentrations (would cause further depolarization)
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Page 3 and 4: BIMM118 • Ganglia close to the in
Page 5 and 6: BIMM118 Receptors: • Cholinergic
Page 7 and 8: BIMM118 Cholinergic System - Agonis
Page 15: BIMM118 Cholinergic System - Antago
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Page 21: BIMM118 Cholinergic System Parasymp

Autonomic Nervous System

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