Autonomic Nervous System

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BIMM118 Cholinergic receptors: • Muscarinic receptors: Hetrotrimeric G protein-coupled – CNS, gastric mucosa: M1 – Cardiac: M2 – Glandular/Smooth muscle: M3 • Nicotinic receptors: Ion channel-coupled – Muscle type (motor endplate) – Ganglion type – CNS type Cholinergic <strong>System</strong> Acetylcholine is rapidly hydrolyzed by a membrane-associated Acetylcholinesterase in the synaptic cleft
BIMM118 Cholinergic <strong>System</strong> - Agonists = Cholinomimetics = Parasympathomimetics Two main classes: • Direct Parasympathomimetics: – Have affinity for M (and/or N receptors) => mimic AcCholine – Act mostly on the M type receptors (not subtype selective) Exception: Nicotine, (Muscle N type only: Tubocurarine, Succinylcholine) • Indirect Parasympathomimetics : – Inhibit the activity of Acetylcholinesterase => [AcCholine] increased
Page 1 and 2: BIMM118 Autonomic Nervous System
Page 3 and 4: BIMM118 • Ganglia close to the in
Page 5: BIMM118 Receptors: • Cholinergic
Page 9 and 10: BIMM118 Cholinergic System - Agonis
Page 15 and 16: BIMM118 Cholinergic System - Antago
Page 21: BIMM118 Cholinergic System Parasymp

Autonomic Nervous System

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