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The Molecular Pathogenesis of Cancer Joan Brugge Cell Biology ...

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Delicate Balance <strong>of</strong> “<strong>of</strong>f” and “on” Controls<br />

Some<br />

proteins tell<br />

promote cells<br />

to proliferate.<br />

<strong>The</strong>se are overproduced<br />

or mutated<br />

causing them to always<br />

ON in cancer.<br />

Other<br />

proteins halt<br />

division or tell<br />

cells to die.<br />

<strong>The</strong>se are lost or<br />

underproduced in<br />

cancer.

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