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The Molecular Pathogenesis of Cancer Joan Brugge Cell Biology ...

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Initiation and Progression <strong>of</strong> Breast <strong>Cancer</strong><br />

Integrin Signaling<br />

Loss <strong>of</strong> growth<br />

suppressor<br />

Amplification <strong>of</strong><br />

survival protein<br />

Breast <strong>Cancer</strong> Genes<br />

Induction <strong>of</strong> an<br />

invasive protein<br />

Normal Gland<br />

Vav<br />

Rac<br />

Cbl<br />

Hyperplasia<br />

Akt<br />

Carcinoma in situ<br />

Invasive Carcinoma<br />

Jnk<br />

Erk<br />

Lamellipodia

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