The Molecular Pathogenesis of Cancer Joan Brugge Cell Biology ...

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Future Drugs • Requires understanding of the pathways that drive the formation of different types of tumors • Need to identify which proteins of the many that are altered play a primary role in the disease and develop strategies to inhibit these diseases. • Initial successes in breast cancer and leukemias give hope for the future.
HELP! • Get students excited about what is happening in biology research • Give them a chance to experience the thrill of discovery, no matter how trivial • Contact congressman to support continued increases in NIH and NCI budget Reducing cancer death by 20 percent would return $10 trillion dollars to the Americans!
Page 1 and 2: The Molecular Pathogenesis of Cance
Page 3 and 4: Challenge: To Identify the Achilles
Page 5 and 6: Different Stages and Grades of Brea
Page 7 and 8: Initiation and Progression of Breas
Page 9 and 10: Most Cancers Contain Gross Chromoso
Page 11 and 12: Role of Proteins in Cells Proteins
Page 13 and 14: Initiation and Progression of Breas
Page 15 and 16: “Genomics” Approaches
Page 17 and 18: Which of the 100’s of Altered Gen
Page 19 and 20: Model of Breast Epithelial Acini ht
Page 21 and 22: Reconstruction of Tumor Phenotype G
Page 23 and 24: Laboratory Cancer Model Normal stru
Page 25 and 26: HER2 Induces Structures that Resemb
Page 27 and 28: Pathways to Luminal Filling Bcl-2/B
Page 29 and 30: Ran Expression Induces an Invasive
Page 31 and 32: Designer Drugs- Hope for the Future
Page 33: Anti-Estrogen Therapy Estrogen x x
Page 37 and 38: How do Our Genes Get Mutated • So
Page 39: Non-genetic Factors that Influence

The Molecular Pathogenesis of Cancer Joan Brugge Cell Biology ...

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