Advanced statistical analysis of epidemiological studies

Multi-state models
Survival data = cohort studies with a single outcome
• time from “zero” to event (death)
• right-censoring, delayed entry
• basic quantity:
– death intensity
– = mortality rate
– = hazard function
– = h(t) ≈ Prob(die before t + ∆ | alive t)/∆
✲
0 t t + ∆
2