Study Design Streptococcal Cell Wall Induced Arthritis - MorphoSys
Study Design Streptococcal Cell Wall Induced Arthritis - MorphoSys
Study Design Streptococcal Cell Wall Induced Arthritis - MorphoSys
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MOR103 Antibody Characteristics<br />
6<br />
<strong>Study</strong> MOR103 Antibody<br />
Affinity<br />
(Fab SET)<br />
Inhibits<br />
� Human and rat GM-CSF (K D=0.4pM and 1100pM)<br />
� Binding of GM-CSF to GM-CSFR-α<br />
� TF-1 and FDCP-1 cell proliferation<br />
� GM-CSF induced PMN migration, CD11b expression<br />
and MHC class II up-regulation<br />
� GM-CSF mediated PMN Stat-5 phosphorylation*<br />
SET, solution equilibrium titration<br />
K D, dissociation constant<br />
TF-1, Human erythroleukemic cells<br />
FDCP, Factor dependent cell Paterson (murine bone cells)<br />
PMN, polymorphonuclear neutrophil<br />
Stat-5, Signal Transducer Activator of Transcription-5<br />
* w. GM-CSF<br />
* w/o. GM-CSF<br />
* w. GM-CSF and MOR103<br />
HAH, New York, Nov 2008 | © <strong>MorphoSys</strong> AG
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