Epidemiologic Investigation of Health Effects in Air Force Personnel ...

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List of Figures F_igure ^No^ Page 1 Mortality Analysis Cohorts .. 25 2 Mortality Matrix.. 25 3 Selection Procedure for the Questionnaire, Physical Examination, and Followup Study 28 4 Design Schematic.... 29 5 Effect of Non-Random Loss to Study in The Control Population 45 6 The Replacement Strategy 46 7 Control Replacement for Morbidity and Followup Studies 47 8 Interpretation of Horizontal Comparisons 49 9 False Reporting/Misrepresentation 55 10 Misrepresentation in Ranch Hand II 56 11 Apparent Relative Risk Versus Specificity 57 12 Power Versus Relative Risk, 1:5 Mortality Study by Three Disease Incidences. 67 13 Power Curves of the Marine Study Considering Relative Exposure and Misclassification of the Study Population; 5,900 Marines 68 14 Power Curves of the Marine Study Considering Relative Exposure and Misclassification of the Study Population; 21,900 Marines 69 15 Rationale of Replacement 84 16 Management Structure, 91 A-l 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) 135 A-2 Estimated Identification/Participation of RANCH HAND Population 136 A-3 Study Design Format 137
List of Tables Table No. Page 1 Estimated Quantities of Herbicides and TCDD Sprayed in RVN, Jan 1963 - Feb 1972 4 2 Summary of Descriptive Characteristics of Patients in the VA Herbicide Registry, as of 10 February 1981... 13 3 VA Herbicide Registry Symptom Reporting 13 4 Feasibility of Identifying Aircraft Maintenance Personnel (Total Population) Exposed to Herbicide Orange 19 5 Comparisons of the Study Group to Possible Control Groups by Known and Estimated Factors. 23 6 Results of the Matching Process (1:10) 26 7 Stratified Format of Age-Specific Death Rates 32 8 Format of McNemar's Test... 35 9 Format of Categorical Representation of Retinal Changes 42 10 Format of Pairing for Grades of Retinal Findings 42 11 Power Calculations.,... ,. 58 12 Power Calculations for the Dichotomous Variable Case as a Function of Efficacy of Paired Designs 59 13 Power Calculations as a Function of Herbicide Effect.... 61 14 Mortality Analysis. Power Comparison of the RANCH HAND Study to the Marine Population; 5,900 Marines, Rare Disease 63 15 Mortality Analysis. Power Comparison of the RANCH HAND Study to the Marine Population; 5,900 Marines, Common Disease 64 16 Mortality Analysis. Power Comparison of the RANCH HAND Study to the Marine Population; 21,900 Marines, Rare Disease 65
Page 1 and 2: Item ID Number 01570 Aether Lathrop
Page 3 and 4: NOTICES This initial report was sub
Page 5 and 6: UNCLASSIFIED SECURITY CLASSIFICATIO
Page 7 and 8: Studies Relating to the Possible Lo
Page 9 and 10: 9 15 June 1981 - Discussion of matc
Page 11 and 12: EXECUTIVE PROJECT RANCH HAND II SUM
Page 13 and 14: physical examination data will util
Page 15: CONTENTS (Continued) Page VII. Data
Page 19 and 20: PROJECT RANCH HAND II EPIDEMIOLOGIC
Page 21 and 22: the peer group recommendations were
Page 23 and 24: caused an increase in the rate of c
Page 25 and 26: IV• Synopsis and Discussion of J-
Page 27 and 28: techniques). Initially, adipose tis
Page 29 and 30: in dogs), excretion (2,4,5-T plasma
Page 31 and 32: If the condition is shown to have o
Page 33 and 34: 1979) indicated that most cases of
Page 35 and 36: V. Epidemiologic Study Desi gn: Mat
Page 37 and 38: ase of operations to a new location
Page 39 and 40: as the spraying. The "exposed" grou
Page 41 and 42: Table 5 COMPARISON OF THE STUDY GRO
Page 43 and 44: Figure 1. MORTALITY ANALYSIS COHORT
Page 45 and 46: the historical morbidity study will
Page 47 and 48: FIGURE 4 EXPOSED DESIGN SCHEMATIC R
Page 49 and 50: and 7. These replacements will be c
Page 51 and 52: SMR * M x 100 k I m i M » "Classic
Page 53 and 54: Table 8 FORMAT OF McNEMAR'S TEST CO
Page 55 and 56: [3Xi(t)] The proportional hazards m
Page 57 and 58: history, and review of symptoms wil
Page 59 and 60: (4) Analysi s of Questi onnai re an
Page 61 and 62: for if need be, either by analyzing
Page 63 and 64: FIGURE 5 EFFECT OF NON-RANDOM LOSS
Page 65 and 66: FIGURE 7 CONTROL REPLACEMENT FOR TH
Page 67 and 68:
FIGURE INTERPRETATION OF HORIZONTAL
Page 69 and 70:
group must have varied widely. Expo
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TCDD contamination then did those h
Page 73 and 74:
V I . Specijl ratns The previous di
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Figure 11 APPARENT RELATIVE RISK VE
Page 77 and 78:
(3) Power in the Pichotomous yajijb
Page 79 and 80:
Using pairing to achieve a power of
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FABLE 14 MORTALITY ANALYSIS POWER C
Page 83 and 84:
.E 16 MORTALITY ANALYSIS POWER COMP
Page 85 and 86:
FIGURE 12 CD POWER VERSUS RELATIVE
Page 87 and 88:
IGURE 14 POWER CURVES OF THE MARINE
Page 89 and 90:
Table 18 CONTROL DISTRIBUTIONS BY E
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(a) larger values of D correspond t
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espect to the replacement strategy.
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VII. Data Repository Throughout the
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VIII. Recogni zed Study Pi f f i cu
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aviation trainees (Waters). This st
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G- Loss to Study/Statistica land Bi
Page 103 and 104:
his own state of health, the altera
Page 105 and 106:
concerning exposures to other herbi
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(f) Laboratory J[)ua1Jt,y Control T
Page 109 and 110:
Figure 16 MANAGEMENT STRUCTURE Prog
Page 111 and 112:
X. Repprti ng Procedures Interim sy
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this time, he will be encouraged to
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SECTION B. Conduct of the Examinati
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CLINICAL RECORD NEUROLOGICAL EXAMIN
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XI Ptosis R£7 L £7 • V Motor R
Page 121 and 122:
C. Spec i a1 P rocedu res (1) Nerve
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(5) Cornell Index (CD Self-administ
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(22) Serum Protein Electrophonesis
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(c) Based upon the reports of toxic
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(k) The following tests should be p
Page 131 and 132:
James A. Wright, MD, MPH Major, USA
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xlv • SELECTED BIBLIOGRAPHY (Key
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Rose, J. Q., J. C. Ramsey, T. H. Wi
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H. ANIMAL STUDIES Allen, J. R., D.
Page 139 and 140:
Hardell, L., M. Eriksson, and P. Le
Page 141 and 142:
Gehan, E. 1965b. A generalized two-
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XV. APPENDIX TABLE A-l TABLE A-2 TA
Page 145 and 146:
TABLE A-2 "SYMPTOM COMPLEX" DERIVED
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TABLE A-3 (CONTINUED) DETAILED LIST
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TABLE A-5 STATISTICAL DESCRIPTION O
Page 151 and 152:
STUDY PHASE Morbidity Study Morbidi
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Figure A-l 2, 3, 7, 8-TETRACHLORODI
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S-ijure A-3 STUDY DESIGN FORMAT MOR
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discovers evidence of acute serious
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56CTIOM PHYSICAL EXAMINATION PULSSS
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Deep Biceps Triceps Remarks Reflexe
Page 163 and 164:
DIAGNOSTIC SUMMARY SYNOPSIS OF POSI
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PERONEAL NERVE (_!) Active electrod
Page 167 and 168:
MOTOR CONDUCTION ULNAR NERVE (3) Ac
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(e) Disposition Forward the recorde
Page 171 and 172:
(2) If a subject's measured word re
Page 173 and 174:
diurnal variations and some are aff
Page 175 and 176:
(e) Rat i ona 1 e .for. 1 a borat f
Page 177 and 178:
(7_) (hi) (jj (jj (kj HDL Triglycer
Page 179 and 180:
;AL RECORD ANATOMICAL FIGURE 161
Page 181 and 182:
NERVE CONDUCTION VELOCITIES SOCIAL
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Ranch Hand II: Psychometric De-Brie
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Symbolic representations of these i
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Following the removal of the inelig
Page 189 and 190:
Glossary of Abbreviations ABBREVIAT
Page 191 and 192:
trr Special i rjjjCw iiia.f (1020
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Epidemiologic Investigation of Health Effects in Air Force Personnel ...

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