Epidemiologic Investigation of Health Effects in Air Force Personnel ...

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ALV1N L. YOUNG, Major, USAF Consultant, Environmental Sciences Report SAM-TR- 82-44 EPIDEMIOLOGIC INVESTIGATION OF HEALTH EFFECTS IN AIR FORCE PERSONNEL FOLLOWING EXPOSURE TO HERBICIDES: STUDY PROTOCOL George D. Lathrop, Colonel, USAF, MC William H. Wolfe, Lieutenant Colonel, USAF, MC Richard A. Albanese, M.D. Patricia M. Mpynahan, Colonel, USAF, NC December 1982 Initial Report for Period October 1978 - December 1982 Approved for public release; distribution unlimited. Prepared for: The Surgeon General United States Air Force Washington, D.C. 20314 USAF SCHOOL OF AEROSPACE MEDICINE Aerospace Medical Division (AFSC) Brooks Air Force Base; Texas 78235
NOTICES This initial report was submitted by personnel of the Epidemiology Division and the Data Sciences Division, USAF School of Aerospace Medicine, Aerospace Medical Division, AFSC, Brooks Air Force Base, Texas, under job order 2767-00-01. When Government drawings, specifications, or other data are used for any purpose other than in connection with a definitely Government-related procurement, the United States Government incurs no responsibility or any obligation whatsoever. The fact that the Government may have formulated or in any way supplied the said drawings, specifications, or other data, is not to be regarded by implication, or otherwise in any manner construed, as licensing the holder, or any other person or corporation; or as conveying any rights or permission to manufacture, use, or sell any patented invention that may in any way be related thereto. The Office of Public Affairs has reviewed this report, and it is releasable to the National Technical Information Service, where it will be available to the general public, including foreign nationals. This report has been reviewed and is approved for publication. WILLIAM H. W0fcfE, Lt Col, USAF, MC Project Scientist GEORGE. LATHROP, Colonel, USAF, MC Supervisor ROY L. DEHART Colonel, USAF, MC Commander
Page 1: Item ID Number 01570 Aether Lathrop
Page 5 and 6: UNCLASSIFIED SECURITY CLASSIFICATIO
Page 7 and 8: Studies Relating to the Possible Lo
Page 9 and 10: 9 15 June 1981 - Discussion of matc
Page 11 and 12: EXECUTIVE PROJECT RANCH HAND II SUM
Page 13 and 14: physical examination data will util
Page 15 and 16: CONTENTS (Continued) Page VII. Data
Page 17 and 18: List of Tables Table No. Page 1 Est
Page 19 and 20: PROJECT RANCH HAND II EPIDEMIOLOGIC
Page 21 and 22: the peer group recommendations were
Page 23 and 24: caused an increase in the rate of c
Page 25 and 26: IV• Synopsis and Discussion of J-
Page 27 and 28: techniques). Initially, adipose tis
Page 29 and 30: in dogs), excretion (2,4,5-T plasma
Page 31 and 32: If the condition is shown to have o
Page 33 and 34: 1979) indicated that most cases of
Page 35 and 36: V. Epidemiologic Study Desi gn: Mat
Page 37 and 38: ase of operations to a new location
Page 39 and 40: as the spraying. The "exposed" grou
Page 41 and 42: Table 5 COMPARISON OF THE STUDY GRO
Page 43 and 44: Figure 1. MORTALITY ANALYSIS COHORT
Page 45 and 46: the historical morbidity study will
Page 47 and 48: FIGURE 4 EXPOSED DESIGN SCHEMATIC R
Page 49 and 50: and 7. These replacements will be c
Page 51 and 52: SMR * M x 100 k I m i M » "Classic
Page 53 and 54:
Table 8 FORMAT OF McNEMAR'S TEST CO
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[3Xi(t)] The proportional hazards m
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history, and review of symptoms wil
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(4) Analysi s of Questi onnai re an
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for if need be, either by analyzing
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FIGURE 5 EFFECT OF NON-RANDOM LOSS
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FIGURE 7 CONTROL REPLACEMENT FOR TH
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FIGURE INTERPRETATION OF HORIZONTAL
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group must have varied widely. Expo
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TCDD contamination then did those h
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V I . Specijl ratns The previous di
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Figure 11 APPARENT RELATIVE RISK VE
Page 77 and 78:
(3) Power in the Pichotomous yajijb
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Using pairing to achieve a power of
Page 81 and 82:
FABLE 14 MORTALITY ANALYSIS POWER C
Page 83 and 84:
.E 16 MORTALITY ANALYSIS POWER COMP
Page 85 and 86:
FIGURE 12 CD POWER VERSUS RELATIVE
Page 87 and 88:
IGURE 14 POWER CURVES OF THE MARINE
Page 89 and 90:
Table 18 CONTROL DISTRIBUTIONS BY E
Page 91 and 92:
(a) larger values of D correspond t
Page 93 and 94:
espect to the replacement strategy.
Page 95 and 96:
VII. Data Repository Throughout the
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VIII. Recogni zed Study Pi f f i cu
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aviation trainees (Waters). This st
Page 101 and 102:
G- Loss to Study/Statistica land Bi
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his own state of health, the altera
Page 105 and 106:
concerning exposures to other herbi
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(f) Laboratory J[)ua1Jt,y Control T
Page 109 and 110:
Figure 16 MANAGEMENT STRUCTURE Prog
Page 111 and 112:
X. Repprti ng Procedures Interim sy
Page 113 and 114:
this time, he will be encouraged to
Page 115 and 116:
SECTION B. Conduct of the Examinati
Page 117 and 118:
CLINICAL RECORD NEUROLOGICAL EXAMIN
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XI Ptosis R£7 L £7 • V Motor R
Page 121 and 122:
C. Spec i a1 P rocedu res (1) Nerve
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(5) Cornell Index (CD Self-administ
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(22) Serum Protein Electrophonesis
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(c) Based upon the reports of toxic
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(k) The following tests should be p
Page 131 and 132:
James A. Wright, MD, MPH Major, USA
Page 133 and 134:
xlv • SELECTED BIBLIOGRAPHY (Key
Page 135 and 136:
Rose, J. Q., J. C. Ramsey, T. H. Wi
Page 137 and 138:
H. ANIMAL STUDIES Allen, J. R., D.
Page 139 and 140:
Hardell, L., M. Eriksson, and P. Le
Page 141 and 142:
Gehan, E. 1965b. A generalized two-
Page 143 and 144:
XV. APPENDIX TABLE A-l TABLE A-2 TA
Page 145 and 146:
TABLE A-2 "SYMPTOM COMPLEX" DERIVED
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TABLE A-3 (CONTINUED) DETAILED LIST
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TABLE A-5 STATISTICAL DESCRIPTION O
Page 151 and 152:
STUDY PHASE Morbidity Study Morbidi
Page 153 and 154:
Figure A-l 2, 3, 7, 8-TETRACHLORODI
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S-ijure A-3 STUDY DESIGN FORMAT MOR
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discovers evidence of acute serious
Page 159 and 160:
56CTIOM PHYSICAL EXAMINATION PULSSS
Page 161 and 162:
Deep Biceps Triceps Remarks Reflexe
Page 163 and 164:
DIAGNOSTIC SUMMARY SYNOPSIS OF POSI
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PERONEAL NERVE (_!) Active electrod
Page 167 and 168:
MOTOR CONDUCTION ULNAR NERVE (3) Ac
Page 169 and 170:
(e) Disposition Forward the recorde
Page 171 and 172:
(2) If a subject's measured word re
Page 173 and 174:
diurnal variations and some are aff
Page 175 and 176:
(e) Rat i ona 1 e .for. 1 a borat f
Page 177 and 178:
(7_) (hi) (jj (jj (kj HDL Triglycer
Page 179 and 180:
;AL RECORD ANATOMICAL FIGURE 161
Page 181 and 182:
NERVE CONDUCTION VELOCITIES SOCIAL
Page 183 and 184:
Ranch Hand II: Psychometric De-Brie
Page 185 and 186:
Symbolic representations of these i
Page 187 and 188:
Following the removal of the inelig
Page 189 and 190:
Glossary of Abbreviations ABBREVIAT
Page 191 and 192:
trr Special i rjjjCw iiia.f (1020
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