Epidemiologic Investigation of Health Effects in Air Force Personnel ...

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Analyses of archived samples of Herbicide Purple suggest that the mean concentration of TCDD may have been approximately 33 ppm (Range: 17 to 47 ppm TCDD) while archived samples of Herbicide Orange had a mean concentration of approximately 2 ppm (Range:
caused an increase in the rate of congenital abnormalities, the DOD confined Herbicide Orange spray operations to nonpopulated areas and in April 1970, all uses of the 2,4,5-T containing herbicides were halted. Other non-2,4,5-T herbicides continued to be used until June 1971 and Operation RANCH HAND was officially deactivated in October 1971. In March 1972, all remaining stocks of 2,4,5-T-containing herbicides were removed from RVN, and transported to Johnston Island, Pacific Ocean, for open storage (Project PACER IVY), and eventual incineration at sea in 1977 (Project PACER HO). In 1979, the Environmental Protection Agency (EPA) suspended the use of herbicides containing 2,4,5-T because an epidemiologic study in the United States attributed abortogenic effects to its use.
Page 1 and 2: Item ID Number 01570 Aether Lathrop
Page 3 and 4: NOTICES This initial report was sub
Page 5 and 6: UNCLASSIFIED SECURITY CLASSIFICATIO
Page 7 and 8: Studies Relating to the Possible Lo
Page 9 and 10: 9 15 June 1981 - Discussion of matc
Page 11 and 12: EXECUTIVE PROJECT RANCH HAND II SUM
Page 13 and 14: physical examination data will util
Page 15 and 16: CONTENTS (Continued) Page VII. Data
Page 17 and 18: List of Tables Table No. Page 1 Est
Page 19 and 20: PROJECT RANCH HAND II EPIDEMIOLOGIC
Page 21: the peer group recommendations were
Page 25 and 26: IV• Synopsis and Discussion of J-
Page 27 and 28: techniques). Initially, adipose tis
Page 29 and 30: in dogs), excretion (2,4,5-T plasma
Page 31 and 32: If the condition is shown to have o
Page 33 and 34: 1979) indicated that most cases of
Page 35 and 36: V. Epidemiologic Study Desi gn: Mat
Page 37 and 38: ase of operations to a new location
Page 39 and 40: as the spraying. The "exposed" grou
Page 41 and 42: Table 5 COMPARISON OF THE STUDY GRO
Page 43 and 44: Figure 1. MORTALITY ANALYSIS COHORT
Page 45 and 46: the historical morbidity study will
Page 47 and 48: FIGURE 4 EXPOSED DESIGN SCHEMATIC R
Page 49 and 50: and 7. These replacements will be c
Page 51 and 52: SMR * M x 100 k I m i M » "Classic
Page 53 and 54: Table 8 FORMAT OF McNEMAR'S TEST CO
Page 55 and 56: [3Xi(t)] The proportional hazards m
Page 57 and 58: history, and review of symptoms wil
Page 59 and 60: (4) Analysi s of Questi onnai re an
Page 61 and 62: for if need be, either by analyzing
Page 63 and 64: FIGURE 5 EFFECT OF NON-RANDOM LOSS
Page 65 and 66: FIGURE 7 CONTROL REPLACEMENT FOR TH
Page 67 and 68: FIGURE INTERPRETATION OF HORIZONTAL
Page 69 and 70: group must have varied widely. Expo
Page 71 and 72: TCDD contamination then did those h
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V I . Specijl ratns The previous di
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Figure 11 APPARENT RELATIVE RISK VE
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(3) Power in the Pichotomous yajijb
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Using pairing to achieve a power of
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FABLE 14 MORTALITY ANALYSIS POWER C
Page 83 and 84:
.E 16 MORTALITY ANALYSIS POWER COMP
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FIGURE 12 CD POWER VERSUS RELATIVE
Page 87 and 88:
IGURE 14 POWER CURVES OF THE MARINE
Page 89 and 90:
Table 18 CONTROL DISTRIBUTIONS BY E
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(a) larger values of D correspond t
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espect to the replacement strategy.
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VII. Data Repository Throughout the
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VIII. Recogni zed Study Pi f f i cu
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aviation trainees (Waters). This st
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G- Loss to Study/Statistica land Bi
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his own state of health, the altera
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concerning exposures to other herbi
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(f) Laboratory J[)ua1Jt,y Control T
Page 109 and 110:
Figure 16 MANAGEMENT STRUCTURE Prog
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X. Repprti ng Procedures Interim sy
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this time, he will be encouraged to
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SECTION B. Conduct of the Examinati
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CLINICAL RECORD NEUROLOGICAL EXAMIN
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XI Ptosis R£7 L £7 • V Motor R
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C. Spec i a1 P rocedu res (1) Nerve
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(5) Cornell Index (CD Self-administ
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(22) Serum Protein Electrophonesis
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(c) Based upon the reports of toxic
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(k) The following tests should be p
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James A. Wright, MD, MPH Major, USA
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xlv • SELECTED BIBLIOGRAPHY (Key
Page 135 and 136:
Rose, J. Q., J. C. Ramsey, T. H. Wi
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H. ANIMAL STUDIES Allen, J. R., D.
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Hardell, L., M. Eriksson, and P. Le
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Gehan, E. 1965b. A generalized two-
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XV. APPENDIX TABLE A-l TABLE A-2 TA
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TABLE A-2 "SYMPTOM COMPLEX" DERIVED
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TABLE A-3 (CONTINUED) DETAILED LIST
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TABLE A-5 STATISTICAL DESCRIPTION O
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STUDY PHASE Morbidity Study Morbidi
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Figure A-l 2, 3, 7, 8-TETRACHLORODI
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S-ijure A-3 STUDY DESIGN FORMAT MOR
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discovers evidence of acute serious
Page 159 and 160:
56CTIOM PHYSICAL EXAMINATION PULSSS
Page 161 and 162:
Deep Biceps Triceps Remarks Reflexe
Page 163 and 164:
DIAGNOSTIC SUMMARY SYNOPSIS OF POSI
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PERONEAL NERVE (_!) Active electrod
Page 167 and 168:
MOTOR CONDUCTION ULNAR NERVE (3) Ac
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(e) Disposition Forward the recorde
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(2) If a subject's measured word re
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diurnal variations and some are aff
Page 175 and 176:
(e) Rat i ona 1 e .for. 1 a borat f
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(7_) (hi) (jj (jj (kj HDL Triglycer
Page 179 and 180:
;AL RECORD ANATOMICAL FIGURE 161
Page 181 and 182:
NERVE CONDUCTION VELOCITIES SOCIAL
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Ranch Hand II: Psychometric De-Brie
Page 185 and 186:
Symbolic representations of these i
Page 187 and 188:
Following the removal of the inelig
Page 189 and 190:
Glossary of Abbreviations ABBREVIAT
Page 191 and 192:
trr Special i rjjjCw iiia.f (1020
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